Preparation and quality control of 153Sm-[tris[1, 10 -phenanthroline] samarium [III]] complex

The 153Sm-[tris[1, 10-phenanthroline] Samarium[III]]complex [153Sm-PL3] was prepared in view of development of targeting therapeutic compounds for malignancies, and interesting in-vitro anti-tumor activities of lanthanide phenanthroline complexes,. Sm-153 chloride was obtained by thermal neutron flux [4 × 1013 n.cm- 2.s-1] of enriched 152Sm2O3 sample, dissolved in acidic media. The labeling was performed in ethanol in 24h, controlled by ITLC [1.0mM DTPA, pH.5, as mobile phase]. The partition coefficient for the labeled compound was also determined. Results: A radiochemical yield of more than 95% was obtained. Radiochemical purity of 96% was obtained using ITLC with specific activity of about 27.75 GBq/mg. The radio-labeled complex was stable in aqueous solution at least 24 hours and no significant amount of free 153Sm was released from the complex. The partition coefficient for the labeled compound was determined [log P. 3.4]. The complex was stable in final formulation for 66h. The biological evaluation of the compound is under investigation. The radiolabeled compound used in this study was a very inexpensive and useful agent for the use as a therapeutic compound

[ effect of purslane powder on chemical characteristics, fatty acids profile and sensory quality of bread]

Purslane seeds provide nutritional value, and have beneficial health effect on the body specially in preventing cardiovascular, cancer and hypertension [high blood pressure] deseases, because it contains omega-3 and omega-6 fatty acids and other nutrients such as antioxidants, tocopherols and dietary fibre. In this study, the effect of incorporating purslane powder into wheat flour with concentrations of 5, 10, 15 and 20% was investigated on dough rheological properties, chemical properties of flour and bread including oil content, fatty acids profile, tocopherols, fat acidity and peroxide. Fatty acids stability during cooking process was also studied. Moreover, sensory characteristics of bread were determined during 5 days of storage. Findings showed that incorporating up to 10% purslane powder led to the weakening of dough rheological behavior in the farinograph. 20% substitution level increased flour fat content, linolenic acid, tocopherols and fat acidity contents. However, peroxide values of samples did not show significant [p>0.05] differences. The amount of fat acidity and peroxide increased during cooking. Linolenic acid was stable to heat, while tocopherols decreased. Bread containing 10% purslane received higher sensory scores compared to other treatments. Bread sensory quality gradually decreased during storage. Incorporating purslane seeds powder increased omega 3 and omega 6 fatty acids in bread. At certain levels [below 10%] of pursalne addition, sensorial properties of bread were improved. Linoleic fatty acid was stable during baking, however, the amount of tocopherols decreased upon baking

Serum concentrations of Helicobacter pylori IgG and the virulence factor CagA in patients with ischaemic heart disease

To compare the serum concentrations of IgG to Helicobacter pylori and its virulence factor CagA in patients with ischaemic heart disease [IHD], we recruited 120 patients with IHD [acute myocardial infarction [AMI] [n = 60]; unstable angina [UA] [n = 60]] and 60 sex- and age-matched healthy controls in this study. The seroprevalence of anti-H. pylori IgG was 86.7% in AMI, 91.7% in UA patients and 58.3% in the control group with mean titres of 33.2 U/ml [standard error [SE] 4.76], 57.96 U/ml [SE 7.54] and 25.72 U/ml [SE 4.01] respectively. The seroprevalence of anti-H. pylori in the patient groups was significantly higher than the control group. The mean levels of anti-H. pylori in the AMI and UA groups were also significantly higher than in the control group. The seroprevalence and mean titre of anti-CagA IgG did not differ significantly between patient and control groups

[Decrease in glutamate level in cerebral cortex and lumbar region of spinal cord of rat: a potential mechanism for minocycline in attenuating morphine-induced tolerance]

Chronic opiate administration induces tolerance to the analgesic effect. Despite extensive investigations in this ground, the precise cellular mechanisms underlying opioid tolerance and dependence remain controversial. Several studies have indicated that glutamatergic transmission and nitric oxide/ Nmethyl D-aspartate [NMDA] pathway could play an important role in morphineinduced tolerance. The main aim of this study was to evaluate the effects of intracerebro- ventricular [ICV] administration of minocycline [a second-generation tetracycline] on morphine-induced tolerance and elevation of glutamate level in cerebral cortex and lumbar region of spinal cord of rats after administration of morphine. Different groups of rats received either morphine [IP] and distilled water [ICV] or morphine [IP] and different doses of minocycline [ICV] or minocycline alone once per day. Nociception was assessed using a hot plate apparatus. The glutamate concentration in both regions was measured with a high performance liquid chromatography [HPLC] apparatus. The results indicated that ICV administration of minocycline with doses of 60, 120, 240 micro g/10micro l/rat attenuated the morphine-induced tolerance and decreased glutamate level in the cerebral cortex. But glutamate level in the lumbar spinal cord decreased after administration of minocycline with doses of 120, 240 micro g/10micro l/rat. We found that central administration of minocycline attenuated morphine-induced increase of glutamate level in the cortex and lumbar spinal cord of rats which can be regarded as a possible mechanism for effect of minocycline on morphine-induced tolerance

[ effect of lavender a aromatherapy on the pain intensity perception and intrapartum outcomes in primipare]

;Labor pain is one of main preoccupations of pregnant women. In this study, our aim was determining the lavender aromatherapy on pain intensity perception and intrapartum outcome in primipare. The present randomize control trial [RCT] study was conducted at Shiraz University of Medical Sciences in 2007. Qne hundred sixty participants, who enrolled voluntarily in our survey and signed the consent form, were divided into two equal groups by simple sampling. The intervention days were randomly separated to avoid any bias. The aroma group received 0.1 milliliter of lavender essential oil mixed with 1 milliliter of distilled water, via tissues attached to their gown close to their nostrils, and the control group received just 2 cc of distilled water via the same way. Pain perception intensity was measured by visual analogue scale [VAS] before the intervention, 30 and 60 minutes after aromatherapy respectively. Both groups were observed during labor time to monitor any aroma side effects. Collected data were analyzed by t-test and chi-square using the SPSS software. Independent T test analysis revealed that the differences in the means of pain perception intensity before intervention between the two groups are not significant while the means of pain perception intensity in the aroma group was lower than that of the control group at 30 and 60 minutes after the interventions [p<0.001]. Paired T test showed that the means of pain perception intensity in the aroma group did not differ before the intervention 30 and 60 minutes after the intervention, but in the control group, had significant increasing in pain perception intensity [p<0.001] was seen. Aromatherapy with lavender did not affect the duration of labor phases and Apgar score. The present study revealed that aromatherapy with lavender affects pain perception of labor pain in the aroma group, but did not affect duration of labor phases and Apgar score

[Comparison of the quality of life in patients with chronic obstructive pulmonary disease and control group]

Chronic obstructive pulmonary disease [COPD] is the fourth cause of mortality and a leading cause of chronic disability worldwide. Given the nature of the disease and lack of any effective treatment, it can profoundly affect the quality of life [QOL] or patients. Studies about the effect of COPD on QOL have yielded contradictory results: however, most studies suggest that COPD negatively affects QOL. QOL is a concept which is influenced by bio-psycho-social factors. In this study, we assessed the effect of COPD on QOL of a group of Iranian patients. In this case we assessed QOL in two groups, each consisting of 80 COPD patients as cases and 80 healthy persons control group matched for age, sex, marital status and education and comparatively similar socioeconomic and cultural status. The brief WHO-QOL questionnaire was used. Data were analyzed with SPSS10 using control study, we as t-test. The results were expressed as mean and standard deviations and significance level was set at 0.05. Analysis of data showed, that mean QOL score and mean scores of the five aspects of QOL, i.e. disease, independent life, social relations, physical sensations and mental welfare in the COPD group was significantly lower than in the control group [P<0.05]. Our findings are indicative of the negative effect of COPD on QOL in particular. The significantly low levels of QOL in COPD patients demonstrates that COPD affects not only the patients' physical health but also other aspects of their lives, leading to decreased QOL. Thus, in spite of ongoing disease, interventions in these aspects of the patients' lives can improve QOL as a comprehensive and holistic therapeutic goal

[Angiographic findings of arterial injuries in extremity trauma]

Nowadays traumatic injuries are the third cause of mortality in human societies and vascular injury as a main part of them are one of the main problems in medicine. Tissue ischemia resulted from vascular injuries is an emergency and if it continues irreversible ischemia and damage will result after 6 hours. In vascular injuries, early diagnosis and treatment is very important. Since the causes, types and resulting damages are different in our country from developed countries, we designed this study to compare these factors based on angiography which is the method of choice in vascular injuries. In this descriptive - analytical study, 75 patients with vascular injuries were studied by angiography in Imam Khomeini Hospital of Tabriz during 12 months. 94.7% of our patients were male and remaining 5.3% were female. The most common cause of trauma in this study was traffic accidents [93.3%] and the most common site of trauma was leg [62.2%] and associated fracture was detected in 86.75% of cases. The most common fracture was double fracture of leg [55.4%]. The most common injured artery was anterior tibial artery [36%] and the most common type of vascular injuries was complete arterial occlusion [62.7%]. Vascular injuries were more common in young males than the other groups and the most common cause was blunt trauma specially motorcycle accidents

Randomized comparison of vaginal dinoprostone and high dose oxytocin of labor: safety and efficacy

Unripe cervix is the most important factor in failure of labor induction. This study is conducted to compare the efficacy and side effects of Dinoproston and high dose oxytocin as ripening agents in labor induction. In this double blinded randomized clinical trial, 1290 women with unfavorable cervix who underwent labor induction were randomly assigned to vaginal Dinoproston [9 mg] or intravenous high dose Oxytocin [6miu/min] groups. Initial 12 hours Bishop-Score, labor induction to labor duration, delivery type, 1 and 5 minute APGAR, side effects on mother or neonate, hospitalization duration and hospitalization costs were recorded. Data were analysed using t and Chi-square tests by means of Minitab statistical shoftware. The results showed that vaginal Dinoproston was effective in shortening latent phase of labor [P<0.01]. But, mean Bishop-Score over the initial 12 hours, the interval between labor induction to delivery, and side effects for mother or neonate were not different between the two groups. Based on the results, although hospitalization duration was not different between the groups, hospitalization costs for Dinoproston group was significantly higher [P<0.05] It seems that inspite of shortening the latent phase of labor in vaginal Dinoproston group, it is not more effective than high dose Osytocin as an adjuvant to labor induction in women with unfavorable cervix