[Evaluation of analgesic effect of sesame oil and lecithin diets in hot plate and formalin test on aged male rats]

Sesame oil is applied in physiological research as a solvent. It contains unsaturated fatty acids such as linoleic acid, sesamol and lecithin. In his research effect of dietary sesame oil on pain perception was studied. N-MRI male rats [360 +/- 20 g] were used. Animals divided to two groups: 1] control group and 2] experimental group [three subgroups that ate dietary plats that contain 10% sesame oil for 28, 42 and 56 days respectively and a subgroup ate dietary plats that contain 1% lecithin]. After 28, 42 and 56 days pain was evaluateded by digital hot plate and formalin test. Data was analyzed by one way ANOVA or T- test. Hot plate test: Sesame oil diet decreased pain in the 28, 42, 56 days significantly. Formalin test: Sesame oil diet decreased pain only in 42 days [p<0.02] significantly in early phase. Sesame oil diet decreased pain in the 28 days [p<0.0001] and 42 days [p<0.03] and 56 days [p<0.001] significantly in late phase of formalin test and also we found significant difference between control and lecithin group [p<0.006] in late phase. Hot plate test: Dietary plats [10% sesame oil] decreased acute pain perception in all experimental groups [p<0.03]. Our data indicated that dietary sesame oil could increase pain threshold. It seems that sesame oil lecithin [as a source for acetylcholine] or unsaturated fatty acid [altered plasma membrane properties or PGs metabolism] involve in this pain threshold alternation

effect of sesame oil on blood cholesterol level in aged and young rats

Sesame oil includes unsaturated fatty acids and phosphatidyle choline [lecithin]. Regarding to nutritional properties and lack of cardiovascular side effects of sesame oil, its effect on blood cholesterol level in aged and young rats were studied. In this study, aged and young rats were assigned into four groups of eight as follows. One group received ordinary diet, as control and other groups received additional sesame oil 10% for 2,3 and 4 weeks, respectively. Finally, blood samples were obtained from rat hearts and were studied by enzymatic methods. Total cholesterol level was statistically lower in both young and aged rats receiving sesame oil 10% for 2,3 and 4 weeks, compared with control groups [p<0.05]. This study showed that sesame oil is able to decrease blood cholesterol level