Study on the effect of hyoscine-N-butylbromide suppository on pain and process of Labor

Labor is a painful process and one of the midwives duties is trying to reduce the intensity of labor pain, in which reduction of duration of clinical stages of labor has always been considered. The objective of this study was to evaluate the effect of hyoscine suppository on labor pain and process of labor. This double-blind clinical trial was down on 130 nulliparous pregnant women who referred to Ahvaz Sina hospital for parturition. A hyoscine suppository was given to case group and a placebo suppository was given to control group at beginning of active phase of labor, rectally. Then the labor pain mean, cervical dilatation and effacement progress, active phase and second stage duration and delivery type were recorded. The data were analyzed using T, Chi square and Fisher tests in 0.05 significant level in SPSS Version 15.0. were significant differences between mean of cervical dilatation and effacement 1 and 2 h after intervention in both groups [P<0.0001]. The active phase and second stage duration in case group were less than control group significantly [P=0.007]. Caesarean section rate in the case group was less than control group, but the difference was not significant [P=:0.07]. Labor pain intensity had not significant difference in both groups. There were no differences in fetal heart rate, maternal pulse rate and blood pressure and neonatal APGAR score between both groups. It seems that hyoscine suppository can be used to accelerate the process of labor and reduce duration of labor pain, effectively, but does not reduce labor pain

Preparation and evaluation of pellets using acacia and tragacanth by extrusion-spheronization

Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs [ibuprofen and theophylline] to form spherical pellets by extrusion-spheronization was investigated. Formulations containing different ratios of acacia and tragacanth [8:2, 9:1, and 10:0] and different drug concentrations [20%, 40%, and 60%] were prepared, on the basis of a 3[2] full factorial design. Pellet properties, such as aspect ratio, sphericity [image analysis], crushing strength and elastic modulus [mechanical tests], mean dissolution time, and dissolution profiles were evaluated. The effect of particular factors on responses was determined by linear regression analysis. The sphericity, drug release rate, and the mechanical properties of the pellets were: affected by the amounts and types of the drugs, and the ratio of the gums. Acacia, relative to tragacanth, produced pellets with higher mechanical strength and a faster drug release rate. Addition of small amounts of tragacanth to ibuprofen formulations resulted in matrix pellets with slow drug release. The results showed that acacia and tragacanth can be used successfully as 2 natural binders in the pellet formulations