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Biol. Res ; 40(2): 97-112, 2007. ilus
Article Dans Anglais | LILACS | ID: lil-468181

Résumé

During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article.


Sujets)
Animaux , Humains , Immunité innée/immunologie , Infections/immunologie , Inflammation/immunologie , Récepteurs de type Toll/immunologie , Immunité innée/physiologie , Infections/microbiologie , Infections/virologie , Inflammation/microbiologie , Inflammation/virologie , /immunologie , Protein-Serine-Threonine Kinases/immunologie , Récepteurs de type Toll/physiologie
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