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Objective To observe the effect of Shenfuqing injection combined with glucocorticoidonthe treatment of septic shock.Methods 93 cases from October 2013 to June 2015 were randomly divided into the observation group(47 cases) and the control group(46 cases).On the basis of anti infection, the observation group were given Shenfu injection combined with green glucocorticoid, and the control group were given glucocorticoid.Acute physiology and chronic health evaluation (APACHE-II score), down calcium original (PCT), high-sensitivity C-reactive protein (hs-CRP), interleukin-10 (IL-10), interleukin-1 (IL-1), interleukin-6 (IL-6), and effect in the two groups were followed-up and compared.Results APACHE-II score, PCT respectivelywere(41.69±6.25)points and (3.01±0.73)ng/mL, which were lower than (52.19±7.06) points and (4.52±1.04)ng/mL in the control group, and the difference is significant (P<0.05).hs-CRP and IL-10 were(16.38±2.45)mg/L and (26.08±3.34)pg/mL in the observation group, which were lower than (21.69±3.02)mg/L and (32.18±4.17)pg/mL in the control group, the difference was significant (P<0.05).IL-1 and IL-6 were (6.49±2.00)ng/Land (15.62±5.67)pg/mL in the observation group, which were lower than (10.45±2.26)ng/L and (26.19±7.02) pg/mLin the control group, and the difference was significant (P<0.05).The total effective rate was 74.47%, which was significantly lower than 52.17% in the control group, and the difference was significant (P<0.05).Conclusion It which Shenfuqing injection combined with glucocorticoid was use in the treatment of septic shock can significantly reduce the inflammatory factors, relieve symptoms.
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Objective To compare the expression of renal transforming growth factor-?_1(TGF-?_1),its receptors type Ⅰ and Ⅱ(T?RⅠ and T?R Ⅱ) in two rat models of chronic nephropathy induced by CsA and FK506 respectively.Methods Rat models of chronic CsA-/FK506-induced nephropathy were established by administering sandimun Neoral and Prograf separately.Then their kidneys were dissected and the protein expression of TGF-?_1,T?RⅠand T?RⅡ,the mRNA levels of T?RⅠ and T?RⅡ was detected by using immunohistochemistry(IHC) and in situ hybridization(ISH) respectively.Results The IHC revealed that the integrated optical densities(IODs) of renal TGF-?_1,T?RⅠ and T?RⅡ were(605.24)?(140.24),(876.28)?(208.73) and(981.59)?(258.65) respectively in CsA-treated rats,(488.37)?(101.76),(586.63)?(131.21) and(543.34)?(105.26) respectively in FK506-treated ones.The ISH indicated that the IODs of renal T?RⅠ and T?RⅡ mRNA were(905.08)?(158.75) and(1090.92)?(242.73) respectively in CsA-treated rats,(661.37)?(205.65) and(716.27)?(195.55) respectively in FK506-treated ones.The difference of the above-mentioned five factors between the two groups was significant(P
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Objective To investigate the expression of inducible nitric oxide synthase (iNOS) and p53 protein in hepatocellular carcinoma (HCC) and their relationship with angiogenesis. Methods Immunohistochemical method and image analysis technique were used to detect the expression of iNOS and p53 protein in tumor tissue sections of 59 HCC patients. Microvessel density (MVD) was counted by immunohistochemical staining with anti CD34 antibody.Results ①The expression rates of iNOS and p53 were 81.4%(48/59), 64.4%(38/59) in HCC patients, respectively. The expression intensities of iNOS and p53 were 5 635?1 287, 3 352?873 in HCC patients, respectively. ②MVD was 32.5?2.73 in the tumor tissue of HCC patients. ③The expression of iNOS was correlated with the expression of p53 and MVD in HCC patients ( P
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Objective To investigate the feasibility of unilateral neck exploration for parathyroid adenoma. Methods The clinical data of preoperative image localization and intraoperative unilateral neck exploration of 15 cases of parathyroid adenoma from 1996 to 2002 in our hospital were analyzed retrospectively. Results Unilateral neck explorations of the 15 cases were performed successfully with the guidance of preoperative ultrasonography , CT, MRI and 99m Tc MIBI scans, and the treatment effect was satisfactory. Conclusion Unilateral neck exploration of parathyroid adenoma could be feasible if accurate preoperative image localizations are available.