Comparison of high sensitivity C-reactive protein level between obese and non-obese pregnant women

To find out whether obesity is associated with low grade systemic inflammation as measured by serum c-reactive proteins [CRP] levels. Cooperative Observational Study. This was conducted in the department of Physiology BMSI, JPMC with the collaboration of gynecology and obstetric department of JPMC Karachi from October 2008 to May 2009. This study includes thirty obese pregnant women and thirty normal weight pregnant women as a control group of similar age, sex, height and gestational age. Subjects were randomly selected from gynae OPD of JPMC Karachi. The mean values of C - reactive protein concentration was higher in obese pregnant women as compared with control group [4.3 +/- 0.16 mg/L vs 9.0 +/- 12 mg/L]. It showed statistically significant positive correlation with body mass index [BMI]. Higher BMI was associated with higher C-Reactive proteins concentration. These findings suggest a state of low-grade systemic inflammation in obese pregnant women

Role of glycemic control and blood pressure in the development of microalbuminuria in NIDDM patients

To assess the relationship of elevated urinary albumin excretion to glycated hemoglobin and increased blood pressure in non-insulin-dependent diabetic patients. Analysis of glycated hemoglobin, blood pressure, serum and urinary creatinine, body mass index in groups I, II and III, i.e., 21-120, 1 21-170 and 171-200 micro g/min, respectively, based on rate of albumin excretion in 24 hours urine samples of patients with NIDDM. Department of Biochemistry, Basic Medical Sciences Institute and Diabetic Clinic of Jinnah Postgraduate Medical Centre, Karachi. A total of one hundred patients having NIDDM diagnosed at least two years previously and 25 apparently healthy subjects as control with similar socioeconomic status were selected. Serum glycated hemoglobin, urinary albumin, albumin creatinine ratio and creatinine clearance were significantly increased in all groups when compared to controls, whereas systolic blood pressure of group-Ill was highly significant. The results of this study prove the effect of poor glycemic control and increased blood pressure on development of microalbuminuria in NIDDM patients