Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Journal of Central South University(Medical Sciences) ; (12): 241-245, 2007.
Article Dans Chinois | WPRIM | ID: wpr-813900

Résumé

OBJECTIVE@#To investigate the correlation between male infertility and Y chromosome microdeletions of azoospermia factor (AZF) regions, and to establish a reliable genetic diagnosis in idiopathic infertile male patients with azoospermia or severe oligozoospermia.@*METHODS@#Multiplex PCR amplification of 6 sequence-tagged sites in AZF regions of the Y chromosome was examined among 100 normal karyotype male patients with azoospermia or oligozoospermia.@*RESULTS@#Four patients (4%) had Y chromosome microdeletions, the microdeletions of 3 patients were idiopathic azoospermic and those of the other 1 patient were secretory azoospermia.@*CONCLUSION@#The PCR-based Y chromosome microdeletion screening is simple and effective in the diagnosis of patients with severe male infertility. Microdeletion of Y chromosome is one of the major causes of severe dyszooospermia.


Sujets)
Adulte , Humains , Mâle , Azoospermie , Génétique , Délétion de segment de chromosome , Chromosomes Y humains , Génétique , Locus génétiques , Infertilité masculine , Diagnostic , Génétique , Caryotypage , Oligospermie , Génétique , Protéines du plasma séminal , Génétique
SÉLECTION CITATIONS
Détails de la recherche