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1.
Indian J Exp Biol ; 2011 May; 49(5): 343-351
Article Dans Anglais | IMSEAR | ID: sea-145136

Résumé

There is little evidence regarding role of B. malabaricum in the treatment of inflammatory bowel disease (IBD); though it is clinically employed as a constituent of a polyherbal preparation for IBD. To establish its role as a monotherapy for IBD, preliminary phytochemical screening of aqueous extract of B. malabaricum (AEBM) was undertaken. Subsequently, its protective effect in indomethacin and iodoacetamide induced colitis in rats (45, 90, 180, 270 mg/kg) and acetic acid induced colitis in mice (65, 130, 250, 500 mg/kg) was assessed. AEBM (270 mg/kg) in indomethacin and iodoacetamide induced colitis significantly reduced the ulcer score and myeloperoxidase (MPO) activity. AEBM/500 mg/kg dose/significantly reduced the ulcer score and MPO activity in acetic acid induced colitis. The extract (270 mg/kg in rats and 500 mg/kg in mice) was found to be comparable with prednisolone (10 mg/kg) and 5-aminosalicylic acid (5-ASA) (100 mg/kg) used as standard treatments. AEBM provided reduction in edema of the intestinal tissues, ulcer protection and lowering of MPO activity in a dose dependent manner. AEBM (500 mg/kg) significantly reduced colonic and serum TNF-α level when compared with the positive control in acetic acid induced colitis model. The results suggest a protective role of AEBM in IBD.

2.
Indian J Exp Biol ; 1999 Mar; 37(3): 258-61
Article Dans Anglais | IMSEAR | ID: sea-55997

Résumé

Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 micrograms/ml. C. deodara wood oil also significantly inhibited the enzyme lipoxygenase at a concentration of 200 micrograms/ml. Thus, the anti-inflammatory activity of C. deodara wood oil could be attributed to its mast cell stabilizing activity and the inhibition of leukotriene synthesis.


Sujets)
Animaux , Anti-inflammatoires non stéroïdiens/administration et posologie , Dégranulation cellulaire/effets des médicaments et des substances chimiques , Oedème/induit chimiquement , Inhibiteurs de la lipoxygénase/administration et posologie , Mâle , Mastocytes/effets des médicaments et des substances chimiques , Huiles végétales/administration et posologie , Rats , Rat Wistar , Arbres , 4-Méthoxyphénéthyl-méthyl-amine/toxicité
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