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1.
Asian Pac J Allergy Immunol ; 2008 Jun-Sep; 26(2-3): 171-81
Article Dans Anglais | IMSEAR | ID: sea-36499

Résumé

Human pregnancy is a complex process. Placental development depends on the function of secretory molecules produced by placental trophoblast cells as well as by maternal uterine immune cells within the decidua. These decidual immune cells are T cells, natural killer cells, macrophages and dendritic cells. The interactions between the trophoblast cells and the maternal immune cells have an impact on the outcome of the pregnancy. Knowledge about the phenotypes and functions of the maternal immune cells in normal and pathological pregnancies including recurrent spontaneous abortions, preeclampsia and hydatidiform moles may improve our understanding of the immunobiology of the normal pregnancy as a whole and may provide approaches for improving the treatment of pathological pregnancies.


Sujets)
Avortements à répétition/sang , Caduques/vascularisation , Femelle , Humains , Môle hydatiforme/sang , Immunité cellulaire , Circulation placentaire/immunologie , Placentation/immunologie , Pré-éclampsie/sang , Grossesse/immunologie , Trophoblastes/immunologie , Utérus/anatomopathologie
2.
Southeast Asian J Trop Med Public Health ; 2008 Sep; 39(5): 837-47
Article Dans Anglais | IMSEAR | ID: sea-31569

Résumé

The outbreak of highly pathogenic avian influenza (HPAI) viruses has severely disrupted poultry production and trade. Humans have been infected with HPAI H5N1 viruses and many have died. The nonstructural (NS) proteins of the virus are a factor that determines virulence. In this report, 80 NS genes of H5N1 HPAI viruses isolated from Thailand were completely sequenced and phylogenically analyzed. The percentages of identity and variable site NS1 genes were similar to NS2/nuclear export protein (NEP) genes. All NS1 genes from the samples were located in allelic group A. The NS1 and NS2/NEP proteins possess 225 and 121 amino acids, respectively. All NS1 protein samples had five amino acid deletions typical of avian influenza viruses isolated since 2002. An amino acid substitution at position 92 (G92E) of the NS1 protein, known to promote the inhibition of host immune responses, was also found in the samples.


Sujets)
Animaux , Génome viral , Sous-type H5N1 du virus de la grippe A/génétique , Phylogenèse , Réaction de polymérisation en chaîne , Volaille , Analyse de séquence d'ADN , Thaïlande/épidémiologie , Protéines virales non structurales/génétique , Facteurs de virulence/génétique
3.
Southeast Asian J Trop Med Public Health ; 2008 May; 39(3): 373-82
Article Dans Anglais | IMSEAR | ID: sea-30813

Résumé

This is the first report of the whole genome sequence of influenza A virus in an aquatic resident bird of Thailand. It was categorized into genotype Z according to its characteristics of a 20 amino acid deletion in neuraminidase and a five amino acid deletion in the nonstructural protein. The indicator for a highly pathogenic trait of the virus is the presence of a polybasic amino acid sequence at the cleavage site of HA0. The feature of resistance to the antiviral drug amantadine is found at the 31st amino acid position of M2 (serine to asparagine). Phylogenic analyses revealed that virus A/little grebe/Thailand/Phichit-01/2004 (H5N1) is closely related to the chicken and human isolates recovered from Thailand. The high degrees of similarity among the sequences and phylogenic trees indicate there was no difference between the viruses isolated from poultry and aquatic birds in Thailand at the time of study. The results also suggest the source of H5N1 avian influenza virus in the little grebe and others in Thailand may have the same origin.


Sujets)
Séquence d'acides aminés , Animaux , Génome viral , Sous-type H5N1 du virus de la grippe A/génétique , Données de séquences moléculaires , Phylogenèse , Volaille , Thaïlande
4.
Asian Pac J Allergy Immunol ; 2008 Mar; 26(1): 63-9
Article Dans Anglais | IMSEAR | ID: sea-36697

Résumé

Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p < 0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection.


Sujets)
Adulte , Burkholderia pseudomallei/immunologie , Diabète de type 1/immunologie , Diabète de type 2/immunologie , Humains , Interleukine-17/sang , Interleukine-23/sang , Agranulocytes/immunologie , Mélioïdose/complications , ARN messager/génétique , Lymphocytes T/immunologie
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