1.
Indian J Physiol Pharmacol
;
1980 Oct-Dec; 24(4): 346-50
Article
Dans Anglais
| IMSEAR
| ID: sea-107030
Résumé
Insulin (5 to 40 I.U.) produced dose-dependent positive inotropic effect in the isolated rat heart. The responses to insulin were markedly inhibited in the presence of propranolol (1 . 1X10(-6) M). Insulin responses were markedly reduced in reserpine pretreated (5 mg/kg, i.p.) rats. Theophylline (4.4 mM), the phosphodiesterase inhibitor, potentiated the responses to insulin, whereas imidazole (20 mM), the phosphodiesterase stimulator inhibited the responses to insulin. The data suggest that the positive inotropic effects of insulin in rat heart is mediated through the release of cardiac catecholamines which stimulates beta-adrenoceptors. The final mediator of cardiac action seems to be cyclic-AMP.
Sujets)
Animaux , Interactions médicamenteuses , Femelle , Imidazoles/pharmacologie , Insuline/pharmacologie , Mâle , Contraction myocardique/effets des médicaments et des substances chimiques , Propranolol/pharmacologie , Rats , Activation chimique , Théophylline/pharmacologie
2.
Article
Dans Anglais
| IMSEAR
| ID: sea-22911
3.
J Indian Med Assoc
;
1973 Feb; 60(3): 83-6
Article
Dans Anglais
| IMSEAR
| ID: sea-96740
4.
Indian J Pediatr
;
1967 Dec; 34(239): 437-9
Article
Dans Anglais
| IMSEAR
| ID: sea-79954