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Mem. Inst. Oswaldo Cruz ; 110(1): 151-153, 03/02/2015. tab, graf
Article Dans Anglais | LILACS | ID: lil-741612

Résumé

The Brazilian Amazon Region is a highly endemic area for hepatitis B virus (HBV). However, little is known regarding the genetic variability of the strains circulating in this geographical region. Here, we describe the first full-length genomes of HBV isolated in the Brazilian Amazon Region; these genomes are also the first complete HBV subgenotype D3 genomes reported for Brazil. The genomes of the five Brazilian isolates were all 3,182 base pairs in length and the isolates were classified as belonging to subgenotype D3, subtypes ayw2 (n = 3) and ayw3 (n = 2). Phylogenetic analysis suggested that the Brazilian sequences are not likely to be closely related to European D3 sequences. Such results will contribute to further epidemiological and evolutionary studies of HBV.


Sujets)
Humains , Carcinome hépatocellulaire , Mouvement cellulaire/physiologie , Tumeurs du foie , Matrix metalloproteinase 9/génétique , Transduction du signal/physiologie , Inhibiteur tissulaire de métalloprotéinase-1/génétique , Lignée cellulaire tumorale/cytologie , Lignée cellulaire tumorale/physiologie , Collagenases/génétique , Dipeptides/pharmacologie , Inhibiteurs de métalloprotéinases matricielles , Matrix metalloproteinase 1/génétique , /génétique , /génétique , /génétique , Inhibiteurs de protéases/pharmacologie , Transduction du signal/effets des médicaments et des substances chimiques , Transfection
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