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Chinese Journal of Virology ; (6): 218-223, 2011.
Article Dans Chinois | WPRIM | ID: wpr-286051

Résumé

This study was to investigate the antiviral effects of a hot water soluble extract S-03 isolated from Isatis indigotica root on different subtypes of influenza A and B viruses in MDCK cell cultures, using plaque reduction, immunofluorescence and hemo-agglutination inhibition (HAD) assays. Chemical analysis of the extract S-03 showed that it contained high proportion of polysaccharides. The antiviral effects in vitro showed that the S-03 had no effect on different influenza viruses if the drug was used before virus adsorption, but S-03 showed obvious activities against influenza viruses if treatment after virus adsorption or direct reaction of drug and virus before virus adsorption. Hemagglutination inhibition assay showed that S-03 inhibited HA activities of different human influenza viruses (inhibition concentration ranged from 3.12 to 25 mg/mL), avain influenza viruses (inhibition concentration ranged from 25 to 50 mg/mL). The antiviral effects of S-03 on different influenza A and B viruses in vitro might be through the inhibition of the HA to prevent infection.


Sujets)
Animaux , Chiens , Cellules cultivées , Technique d'immunofluorescence , Tests d'inhibition de l'hémagglutination , Virus de la grippe A , Virus influenza B , Isatis , Chimie , Extraits de plantes , Pharmacologie , Racines de plante
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