Preformulation compatibility study of aceclofenac with tablet excipients [natural and synthetic] using differential scanning calorimetry

Differential scanning calorimetry was used as a tool to study the tablet excipient-Aceclofenac interactions in order to assess their compatibility. Compatibility studies were carried on samples of 1:1 physical mixtures of the drug with various excipients [natural and synthetic] viz., Hydroxy propyl methyl cellulose, Ethyl cellulose, Chitosan, Eudragit, and Magnesium stearate as sustained release polymers and lubricant respectively at room temperature. Aceclofenac was found to be compatible with all the excipients viz. Hydroxy propyl methyl cellulose, Ethyl cellulose, Chitosan, Eudragit and Magnesium stearate

Evaluation of pharmacognostical characteristics of pithecellobium dulce benth. [Leguminosae] - II

The leaves of Pithecellobium dulce Benth. [Leguminosae] have been reported to possess astringent, emollient, abortifiacient and antidiabetic properties. Quercitin, kaempferol, dulcitol and afezilin have been reported from the leaves. Owing to its importance, some pharmacognostical parameters, powder microscopical characters, angle of repose, bulk density, TLC study, IR and UV-Visible finger printing were studied for leaves of Pithecellobium dulce Benth. which will enable the future investigators for identification and characterization of the plant

Hepatoprotective activity of Clerodendron inerme extract

The ethanolic extract of dried leaves of Clerodendron inerme were screened pharmacologically for their hepatoprotective activity against Carbon tetrachloride-induced hepatotoxicity in rats. The ethanolic extract exhibited significant activity by lowering serum levels

Studies on the potentiation analgesic effect of phenytoin and ketorolac with pelitazocine using albino mice by eddy's hot plate method

The analgesic activity was tested by Eddy's hot plate method in albino mice using combination of Pentazocine [1 mg/kg] with Phenytoin [10.20 mg/kg] and Pentazocine [1 mg/kg] with Ketorolac [10.20 mg/kg] was given by intra-peritoneal administration, The results showed a significant increase in reaction time [analgesia] in albino mice and hence the present study indicates that combination of Phenytoin and Ketorolac with Pentazocine has significant prolonged analgesic effect as compared with analgesic effect produced by Pentazocine alone

Identification of sugars and estimation of water content in honey

Honey samples from country drug sellers, street vendors and tribes of Kanchipuram District were subjected to simple Thin Layer Chromatography [TLC] to identify sugars in those samples. Water content estimated by Karl Fischer titration method and refractive indices of the samples found to decrease with an increase in water content

Antimicrobial activity of the extracts of artocarpus heterophyllus

Antimicrobial activity of Benzene, Chloroform and Alcohol extracts of Artocarpus heterophyllus roots were studied against Bacillus subtilis. Escherichia coli. Staphylococcus aureus and Streptococcus pyogenes by disc diffusion method. The extract of roots exhibited significant antimicrobial activity

Effect of diosmin, flavonoid of barosma betulina [rutaceae] on drug induced hepatotoxicity

The flavonoid, Diosmin was tested for hepatoprotective activity against paracetamol induced liver damage in rats. Evaluation done by measuring the reduction in elevated serum levels of SCOT, SGPT, ALP, ACP and Total bilirubin and also by reduction in increased liver weight

Wound healing activity of different marketed ayurvedic tailams

Five Marketed Ayurvedic Tailam Formulations[1] [Table 2]of reputed manufacturers were screened for wound healing activity in different types of wound models in rats [Excision and Incision wound models]. Complete filling and healing of wounds was observed for 12 days after daily application of the tailams. All the tailams produced a significant response in wound healing. The results were also comparable to standard drug Povidone iodine ointment in terms of wound contracting ability, percentage wound closure and tensile strength

Wound healing activity of the extracts of Sida acuta

Leaf extracts of Sida acuta Linn. were screened for wound healing activity in types of wound models in rats [1] Excision and [2] Incision wound model. Complete filling and healing of wounds was observed for 12 days after daily application of the aqueous and alcoholic extracts in the form of an ointment in the concentration of 5% w/w and 10% w/w. Both alcoholic and aqueous extracts of the plant produced a significant response in wound healing. The results were also comparable to standard drug Povidone Iodine ointment in terms of wound contracting ability, percentage wound closure and tensile strength

Effect of chloramphenicol and kinetin on Bio-production of total alkaloid, tannin and ascorbic acid in young aerva lanata [L.] Juss. ex Schultes plants

The present work is aimed at enhancing total beta-carboline alkaloids in young Aerva lanata plants through chloramphenicol and kinetih applications as foliar spray. Chloramphenjcol [120 mg/l] and kinetin [30 mcg/l] showed beneficial effect on total alkaloid and ascorbic acid production in young plants. 'Also, it showed little effect on the production of tannin. The total alkaloid was estimated by precipitation with ammonium reineckate, while tannin and ascorbic acid were determined spectrophotometrically. The total alkaloid increased to 0.827% in root powder as compared with control [0.534%] and it also increased in stem and leaves. The yield of tannin [0.1 66%] in root powder showed very little effect when compared with control [0.148%]. The better yield of ascorbic acid [0.024%] showed in leaves as compared with control [0.018%]. Application of higher concentration of chloramphenicol caused no further increase in total alkaloid production

Effect of chloramphenicol and kinetin on bio-production of total alkaloid and ascorbic acid in young celosia argentea linn. plants

Chloramphenicol and kinetin stimulated the production of alkaloids and ascorbic acid in young Celosia plants. Different concentrations of chloramphenicol and kinetin were applied as foliar spray on four weeks old plants. Chloramphenicol [120 mg/l] and kinetin [30 mcg/1] showed beneficial effect on total alkaloid and ascorbic acid production in young plants. The total alkaloid was determined by precipitation with ammonium reineckate; while the ascorbic acid was estimated colorimetrically. The total alkaloid had increased to 0.147% in root powder as compared with control [0.078%] and had also increased in stem and leaves. The better yield of ascorbic acid [0.587%] showed in leaves as compared with control [0.396%]