Plasminogen, fibrinogen and bradykinins in alveolar osteitis in patients receiving oral contraceptives

Two hundred females were examined for the incidence of alveolar osteitis [dry socket], after simple extraction of a mandibular molar. The control group [100 Patients] included 12% positive cases at the middle of their menstrual cycle. In the contraceptive pill users group, the incidence of alveolar osteitis was 36% at the middle of the tablet cycle No cases were reported during menstruation in both groups. The highest levels of plasma plasminogen and bradykjnin were found at the middle of the tablet cycle. These levels were significantly higher than those found at the middle of the menstrual cycle. Blood level of fibrinogen was significantly reduced in females using pills, compared to the control group at the middle of both cycles. A marked elevation of plasminogen and bradvkinin levels was associated with proportionate decrease in the level of fibrinogen in dry socket eases. The difference between the control and pill users groups was significant

Correlation between fructosamine and glycosamine and glycosylated haemoglobin as indices of glycemic control in diabetic patients

Serum fructosamine and glycosylated haemoglobin H[b]Al[c] level were measured in 25 diabetic patients, insulin dependent [type I] and non-insulin dependent [type II], 10 diabetic patients with nephropathy and 20 pregnant diabetic patients. Both parameters were significantly higher in diabetic patient as compared to normal non-diabetic subjects. A significant correlation was found between fructosamine concentration and H[b]Al[c] in non-diabetic and diabetic subjects. This correlation was also significant in the pregnant diabetic group, in whom a gradual decrease in the levels of fasting serum glucose, fructosamine and H[b]Al[c] was observed with the progress of pregnancy. In cases of diabetic nephropathy, high values of fructosamine and H[b]Al[c] were obtained with significant correlation between the 2 indices

Biochemical studies of safsaf F. used in Egyptian folk medicine as antidiabetic drugs

Phytochemical screening of an aqueous extract of Salix Safsaf F. revealed the presence of salicin, salicylaldhyde, tannins, flavonoids, carbohydrates and sterols. The hypoglyoemic effect of an aqueous extract of Salix Safsaf F. leaves in normal and alloxan diabetic rabbits was studied. The extract was given orally in a dose equivalent to 5 gm of dry powder/kg once and twice/day for 15 days. Alloxan diabetic rabbits showed significant reduction in serum level of glucose and significant increase in serum insulin and C-peptide after Salix treatment in normal rabbits, insignificant change was observed in the serum level of glucose, insulin and C-peptide after treatment with Salix extract for 15 days. No side effects was observed after the use of Salix extract as proved by studying some liver function tests [SGOT, SGPT and alkaline phosphatase], kidney function tests [serum urea and creatinine] and the concentration of hemoglobin in the different groups studied