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Indian J Exp Biol ; 1995 Jan; 33(1): 28-33
Article Dans Anglais | IMSEAR | ID: sea-57540

Résumé

IDPH-8261, methyl alpha-methyl-4-(3-thienyl)benzeneacetate, exhibited marked anti-inflammatory activity in acute, subacute and chronic models of inflammation. In rats, IDPH-8261 exhibited a dose related inhibition of carrageenin-induced rat paw edema and the inhibition was greater than ibuprofen, phenylbutazone, but was three times less than indomethacin. It exhibited anti-inflammatory activity in normal and adrenalectomized rats. It also exhibited the activity against various phlogistic agents. IDPH-8261 exhibited AI activity in subacute granuloma tests. In adjuvant-induced established polyarthritis. IDPH-8261 exhibited anti-arthritic effect at a very low dose (ED50 = 4 mg/kg, p.o.). Ulcerogenic liability was the lowest (UD50 = 180 mg/kg, p.o.), when compared to reference standard drugs. Low toxicity and high efficacy may make this compound a potentially useful therapeutic agent.


Sujets)
Animaux , Anti-inflammatoires non stéroïdiens/synthèse chimique , Carragénane/pharmacologie , Chiens , Oedème/induit chimiquement , Phénylacétates/synthèse chimique , Rats , Ulcère/traitement médicamenteux
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