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Chinese journal of integrative medicine ; (12): 795-800, 2016.
Article Dans Anglais | WPRIM | ID: wpr-301065

Résumé

Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.


Sujets)
Animaux , Humains , Inhibiteurs de l'angiogenèse , Chimie , Utilisations thérapeutiques , Antinéoplasiques , Utilisations thérapeutiques , Médicaments issus de plantes chinoises , Chimie , Utilisations thérapeutiques , Modèles biologiques , Néovascularisation pathologique , Sang , Traitement médicamenteux
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