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1.
Nutrition Research and Practice ; : 248-259, 2022.
Article Dans Anglais | WPRIM | ID: wpr-926823

Résumé

BACKGROUND/OBJECTIVES@#Adequate nutritional intake is essential for good health and well-being. We aimed to compare the nutrient intake from homemade meals, meals sourced externally (“eating out”), and meals from workplace foodservices, as well as the potential association between foodservices used and nutritional quality among adult Korean workers. @*SUBJECTS/METHODS@#We used data from the Korea National Health and Nutrition Examination Survey, a nationwide cross-sectional survey on the health and nutritional status of the Korean population. Data from 6,845 workers aged 20–64 years were included. A survey on dietary behavior and nutrition was conducted using the 24-h dietary recall method.Nutritional quality was examined using the index of nutritional quality (INQ) score. Higher INQ scores reflected poorer nutritional quality, with insufficient intake of a higher number of nutrients. Multivariate linear regression was used to identify the association between the foodservices used and INQ scores after adjusting for other covariates. @*RESULTS@#We found that foodservice users exhibited a higher 1-day intake of total energy and macronutrients (all P < 0.05) and lower INQ scores (P < 0.01) than non-users. The INQ scores for total daily meals decreased with the frequency of foodservice use (P < 0.01). A significant association was observed between the non-use of foodservices and INQ scores (β = 0.29, P < 0.01) after adjusting for other covariates. @*CONCLUSIONS@#The use of workplace foodservices contributed to higher dietary nutritional quality among workers. This study highlights the importance of expanding the scope of workplace foodservices to promote higher nutritional quality and healthy dietary habits among workers.

2.
Yonsei Medical Journal ; : 660-669, 2021.
Article Dans Anglais | WPRIM | ID: wpr-904234

Résumé

Purpose@#The aim of this study was to explore the role of primary care facilities and their support measures in response to coronavirus disease 2019 (COVID-19) and to identify challenges to achieving public–private cooperation in South Korea. @*Materials and Methods@#Twenty-four leading experts were selected and recruited to participate in this iterative web-based Delphi study. An open-ended questionnaire was administered to collect the expert panel’s views in the first round. In the second round, the panel was asked to rate on a 5-point Likert scale their agreement with individual items gleaned from qualitative content analysis of views expressed in the first round. The participants were offered the opportunity to reevaluate and correct their initial responses in subsequent rounds. Responses in the second and following rounds were analyzed using quantitative descriptive statistics. @*Results@#The first and second rounds were completed by 54.2% (n=13/24) and 58.3% (n=14/24) of the selected panel, respectively, while 10 out of these 14 participants completed the third round. The panel cited in-person essential medical services, telehealth for fever/respiratory symptoms, surveillance for influenzae-like illness, and minimization of spread to staff as important and appropriate roles of primary care, which are urgent and feasible during a pandemic. Regarding conditions/support for these roles, the panel indicated that institutional support and funding for separate areas, workforce, and telehealth, along with public-private collaborative governance, are urgent, but not feasible. @*Conclusion@#This study provides guidance on strategies for continuing the required roles of primary care and highlights a need to strengthen public-private partnerships during pandemic events in Korea.

3.
Yonsei Medical Journal ; : 660-669, 2021.
Article Dans Anglais | WPRIM | ID: wpr-896530

Résumé

Purpose@#The aim of this study was to explore the role of primary care facilities and their support measures in response to coronavirus disease 2019 (COVID-19) and to identify challenges to achieving public–private cooperation in South Korea. @*Materials and Methods@#Twenty-four leading experts were selected and recruited to participate in this iterative web-based Delphi study. An open-ended questionnaire was administered to collect the expert panel’s views in the first round. In the second round, the panel was asked to rate on a 5-point Likert scale their agreement with individual items gleaned from qualitative content analysis of views expressed in the first round. The participants were offered the opportunity to reevaluate and correct their initial responses in subsequent rounds. Responses in the second and following rounds were analyzed using quantitative descriptive statistics. @*Results@#The first and second rounds were completed by 54.2% (n=13/24) and 58.3% (n=14/24) of the selected panel, respectively, while 10 out of these 14 participants completed the third round. The panel cited in-person essential medical services, telehealth for fever/respiratory symptoms, surveillance for influenzae-like illness, and minimization of spread to staff as important and appropriate roles of primary care, which are urgent and feasible during a pandemic. Regarding conditions/support for these roles, the panel indicated that institutional support and funding for separate areas, workforce, and telehealth, along with public-private collaborative governance, are urgent, but not feasible. @*Conclusion@#This study provides guidance on strategies for continuing the required roles of primary care and highlights a need to strengthen public-private partnerships during pandemic events in Korea.

4.
Journal of Korean Medical Science ; : e60-2018.
Article Dans Anglais | WPRIM | ID: wpr-764910

Résumé

BACKGROUND: The goal of this study was to analyze the relationship between exercise frequency and all-cause mortality for individuals diagnosed with and without diabetes mellitus (DM). METHODS: We analyzed data for 505,677 participants (53.9% men) in the National Health Insurance Service-National Health Screening (NHIS-HEALS) cohort. The study endpoint variable was all-cause mortality. RESULTS: Frequency of exercise and covariates including age, sex, smoking status, household income, blood pressure, fasting glucose, body mass index, total cholesterol, and Charlson comorbidity index were determined at baseline. Cox proportional hazard regression models were developed to assess the effects of exercise frequency (0, 1–2, 3–4, 5–6, and 7 days per week) on mortality, separately in individuals with and without DM. We found a U-shaped association between exercise frequency and mortality in individuals with and without DM. However, the frequency of exercise associated with the lowest risk of all-cause mortality was 3–4 times per week (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.65–0.73) in individuals without DM, and 5–6 times per week in those with DM (HR, 0.93; 95% CI, 0.78–1.10). CONCLUSION: A moderate frequency of exercise may reduce mortality regardless of the presence or absence of DM; however, when compared to those without the condition, people with DM may need to exercise more often.


Sujets)
Pression sanguine , Indice de masse corporelle , Cholestérol , Études de cohortes , Comorbidité , Diabète , Caractéristiques familiales , Jeûne , Glucose , Corée , Dépistage de masse , Mortalité , Programmes nationaux de santé , Fumée , Fumer
5.
Vascular Specialist International ; : 175-179, 2016.
Article Dans Anglais | WPRIM | ID: wpr-104975

Résumé

PURPOSE: Implementing an inferior vena cava (IVC) filter is a relatively safe procedure but potential negative long-term effects. The complications for filter retrieval have been noted. We examined filter characteristics on pre-retrieval computed tomography (CT) that were associated with complicated retrieval (CR) of IVC filters. MATERIALS AND METHODS: A retrospective review of IVC filter retrievals between January 2008 and June 2014 was performed to identify patients who had undergone a pre-retrieval CT for IVC filter retrieval. CR was defined as the use of nonstandard techniques, procedural time over 30 min, filter fractures, filter tip incorporation into the IVC wall, and retrieval failure. Pre-retrieval CT images were evaluated for tilt angle in the mediolateral and anteroposterior directions, tip embedding into the IVC wall, degree of filter strut perforation, and distance of the filter tip from the nearest renal vein. RESULTS: Of seventy-six patients, twenty-four patients (31.6%) with CRs and 56 patients (73.7%) with non-CR were evaluated for pre-retrieval CT. For IVC filter retrieval with a dwelling time of over 45 days, a tilt of over 15 degrees, the appearance of tip embedding and grade 2 perforation were associated with CR on multivariate analysis. However, for IVC filter retrievals with a dwelling time of less than 45 days, there were no factors associated with CR. CONCLUSION: Pre-retrieval CTs may be more effective for IVC filters with a dwelling time of over 45 days. Therefore, a pre-retrieval CT may be helpful in predicting CR of IVC filters with long dwelling times.


Sujets)
Humains , Ablation de dispositif , Analyse multifactorielle , Veines rénales , Études rétrospectives , Filtres caves , Veine cave inférieure , Thrombose veineuse
6.
Vascular Specialist International ; : 115-119, 2015.
Article Dans Anglais | WPRIM | ID: wpr-108808

Résumé

PURPOSE: The purpose of this study was to evaluate the early and midterm results of superficial femoral artery (SFA) stenting with self-expanding nitinol stents and to identify the factors affecting patency. MATERIALS AND METHODS: SFA stenting was performed in 165 limbs of 117 patients from January 2009 to December 2013. Patients were followed-up for the first occurrence of occlusion or stenosis based on computed tomography and duplex scan results and a decrease in ankle brachial index of >15%. RESULTS: During the follow-up period (mean, 15.3+/-3.2 months), no early thrombotic reocclusions occurred within 30 days, but in-stent restenosis developed in 78 limbs. The primary patency rates at 6, 12, 18, and 24 months were 78%, 66%, 42%, and 22%, respectively, and the secondary patency rates were 85%, 72%, 58%, and 58%, respectively. TASC II C or D lesions, stent length >8 cm, number of patent tibial arteries and diabetes were significantly associated with reintervention. CONCLUSION: The midterm results of stenting for SFA occlusive disease were disappointing because the primary and secondary patency rates at two years were 22% and 58%, respectively. Reintervention after SFA stenting remains a major problem, particularly in patients with diabetes mellitus or long TASC II C or D lesions.


Sujets)
Humains , Index de pression systolique cheville-bras , Sténose pathologique , Diabète , Procédures endovasculaires , Membres , Artère fémorale , Études de suivi , Endoprothèses , Artères tibiales
7.
Vascular Specialist International ; : 130-134, 2015.
Article Dans Anglais | WPRIM | ID: wpr-108805

Résumé

One of the predominant methods for preserving the internal iliac artery (IIA) in aortoiliac aneurysms is to use an iliac bifurcated device (IBD). However, there are a few limitations to the use of IBD in Korea. Our study aims to present the technical aspects of these devices, and to provide a mid-term analysis of IBD. Since 2013, 4 IBDs were used in 4 patients, with a mean follow-up of 14 months (range, 6-22 months). A 100% technical success rate was achieved without mortality and morbidity in our cases. The mean procedural time was 176 min (range, 145-240 min), and the mean contrast dose used was 184 mL (range, 135-220 mL). Type I or III endoleaks and postoperative expansion of the aneurysms weren't observed. Our cases demonstrates that IBD is a relatively safe repair method of aortoiliac aneurysms with preservation of the IIAs. However, a longer follow-up is needed to review the midterm results.


Sujets)
Humains , Anévrysme , Anévrysme de l'aorte abdominale , Endofuite , Procédures endovasculaires , Études de suivi , Artère iliaque , Corée , Mortalité
8.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 89-97, 2015.
Article Dans Anglais | WPRIM | ID: wpr-118750

Résumé

BACKGROUNDS/AIMS: Intrahepatic recurrence is one of the most important causes of compromised prognosis after surgical resection of hepatocellular carcinoma (HCC). This retrospective study was designed to identify and compare the risks of recurrence, early recurrence and multiple recurrences in a single patient population. METHODS: A series of 92 consecutive patients, who received resection for single nodular HCC at our institute from January 2007 to December 2013, were enrolled in this study. The patients were divided into recurrent and non-recurrent groups; the recurrent group was further divided into subgroups by applying two criteria: early and late recurrence (with a cutoff of 18 months), and single and multiple (> or =2) recurrence. The potential risk factors were compared using univariate and multivariate analyses. The subgroup analysis was performed to determine the effects of different cut-off values on the analysis. RESULTS: 41 recurrences (44.6%) occurred during a mean follow-up of 42.4 months. The Child-Pugh score, and the portal vein invasion were found to be independent risk factors of recurrence, but differentiation was the only independent risk factor of early recurrence. The serum alpha-fetoprotein, tumor size, tumor necrosis, and hemorrhage were found to be the risk factors of multiple recurrences according to the univariate analysis, but lacked significance according to the multivariate analysis. When the cutoffs for early and multiple recurrences were changed to 3 nodules, respectively, different risk factors were identified. CONCLUSIONS: Our results implicated that different factors can predict the recurrence, timing, and multiplicity of an HCC recurrence. Further studies should be conducted to prove the complex relationships between tumor burden, invasiveness, and underlying liver cirrhosis for initial tumors, and the timing and multiplicity of recurrent HCC.


Sujets)
Humains , Alphafoetoprotéines , Carcinome hépatocellulaire , Études de suivi , Hémorragie , Cirrhose du foie , Analyse multifactorielle , Nécrose , Veine porte , Pronostic , Récidive , Études rétrospectives , Facteurs de risque , Charge tumorale
9.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 21-25, 2014.
Article Dans Anglais | WPRIM | ID: wpr-81256

Résumé

BACKGROUNDS/AIMS: The post-operative complications and clinical course of pancreaticoduodenectomy (PD) largely depend on the pancreaticojejunostomy (PJ). Several methods of PJ are in clinical use. We analyzed the early results of binding pancreaticojejunostomy (BPJ), a technique reported by SY Peng. METHODS: We retrospectively reviewed the clinical results of patients who received BPJ in Inha University Hospital from 2006 to 2011. 21 BPJs were performed with Peng's method. The definition of postoperative pancreatic fistula (PF) was a high amylase content (>3 times the upper normal serum value) of the drain fluid (of any measurable volume), at any time on or after the 3rd post-operative day. The pancreatic fistula was graded according to the International Study Group for Pancreatic Fistula (ISGPF) guidelines. RESULTS: Of the 21 patients who received BPJ, 11 were male. The median age was 61.2 years. PD surgery included 4 cases of Whipple's procedures and 17 cases of pylorus-preserving PD. According to the post-operative course, 16 patients recovered well with no evidence of PF. A total of 5 patients (23.8%), including 3 grade A PFs and 2 grade C PFs, suffered from a pancreatic fistula. 3 patients with grade A PF recovered with conservative management. CONCLUSIONS: The BPJ appears to be a relatively safe procedure based on this preliminary study, but further study is needed to validate its safety.


Sujets)
Humains , Mâle , Amylases , Fistule pancréatique , Duodénopancréatectomie , Pancréaticojéjunostomie , Études rétrospectives
10.
Annals of Surgical Treatment and Research ; : 161-164, 2014.
Article Dans Anglais | WPRIM | ID: wpr-158579

Résumé

Endotension is an unpredictable late complication of endovascular aortic aneurysm repair (EVAR). This case report will discuss the successful treatment of enlarged aneurysmal sac due to endotension using the relining technique. An 81-year-old male complained of nondecreasing huge aneurysm sac. He had undergone EVAR for infrarenal abdominal aortic aneurysm 7 years prior and no endoleak was found through follow-up. Initially computed tomography-guided sac aspiration was tried, but in vain, Relining using the double barrel technique and tubular endograft for modular diconnection, which was unexpectedly found in the original endograft, were performed sucessfully. During follow-up after the relining procedure, the size of aneurysm sac continued to decrease in size. The relining technique is effective mothod for treating endotension.


Sujets)
Sujet âgé de 80 ans ou plus , Humains , Mâle , Anévrysme , Anévrysme de l'aorte , Anévrysme de l'aorte abdominale , Endofuite , Procédures endovasculaires , Études de suivi
11.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 77-83, 2014.
Article Dans Anglais | WPRIM | ID: wpr-162295

Résumé

BACKGROUNDS/AIMS: We investigated the clinical application of extended distal pancreatectomy in patients with pancreatic neck cancer accompanied by distal pancreatic atrophy. In this study, we have emphasized on the technical aspects of using the linear stapling device for a bulky target organ. METHODS: From March 2010 to September 2013, 46 patients with pancreatic adenocarcinoma, who underwent pancreatic resection with radical intent at our institute, were reviewed retrospectively. Among them, three patients (6.5%) underwent extended distal pancreatectomy. A linear stapling device and vise-grip locking pliers were used for en bloc resection of the distal pancreas, first duodenal portion, and distal common bile duct. The results were compared with those after standard pancreatectomy. RESULTS: All three patients presented with jaundice, and the ratio of pancreatic duct to parenchymal thickness of the pancreatic body was greater than 0.5. Grade A pancreatic fistula developed in all of the cases, but none of these fistulae were lethal. Pathological staging was T3N1M0 in all of the patients. The postoperative daily serum glucose fluctuations and insulin requirements were comparable to those in patients who received pancreaticoduodenectomy or distal pancreatectomy. At the last follow-up, two patients were alive with liver metastasis at 4 and 10 months postoperatively, respectively, and one patient died of liver metastasis at 5 months postoperatively. CONCLUSIONS: While the prognosis of advanced pancreatic neck adenocarcinoma is still dismal, extended distal pancreatectomy is a valid treatment option, especially when there is atrophy of the distal pancreas. Also, the procedure is technically feasible, and further refinement is necessary to improve patient survival.


Sujets)
Humains , Adénocarcinome , Atrophie , Glycémie , Conduit cholédoque , Fistule , Études de suivi , Tumeurs de la tête et du cou , Insuline , Ictère , Foie , Cou , Métastase tumorale , Pancréas , Pancréatectomie , Conduits pancréatiques , Fistule pancréatique , Duodénopancréatectomie , Pronostic , Études rétrospectives
12.
Journal of the Korean Society for Vascular Surgery ; : 103-108, 2013.
Article Dans Anglais | WPRIM | ID: wpr-726633

Résumé

Mechanical closing devices were developed to shorten bed rest following percutaneous vascular intervention, and recently, the devices are replacing the conventional manual compression. Among the closing devices, the Perclose suture-mediated closure system (Perclose/Proglide) is known to be a safe and effective method that permits faster hemostasis and earlier ambulation compared with manual compression. However, with increased usage of femoral closure devices, reports of complications have emerged. Most reported complications are local bleedings, hematomas, and wound infections. Herein, we report a rare case: common femoral artery (CFA) stenosis after using Perclose suture-mediated closure system. After failure of secondary ballooning of the CFA stenotic segment, CFA was opened operatively and we found that snared atheroma by Perclose suture material was occupying the CFA lumen. Endarterectomy was performed for the lesion and the CFA stenosis was improved.


Sujets)
Angioplastie , Alitement , Sténose pathologique , Endartériectomie , Artère fémorale , Hématome , Hémostase , Plaque d'athérosclérose , Matériaux de suture , Marche à pied , Infection de plaie
13.
Journal of the Korean Surgical Society ; : 183-186, 2012.
Article Dans Anglais | WPRIM | ID: wpr-176220

Résumé

Stent fracture is one of the major factors compromising implanted stent patency due to its consequences including in-stent restenosis, thrombosis, perforation, and migration. Stent fracture can occur from stress (extrinsic or intrinsic) and biomechanical forces at different implantation sites. We report on 2 cases of stent fractures and pertinent literature. One patient, a 75-year-old male, presented with recurrence of claudication 14 months after superficial femoral artery stenting; a femoral artery occlusion with stent fracture was found, and he underwent femoropopliteal bypass. The other patient, a 72-year-old male presented with recurrence of claudication; a stent fracture was found without femoral artery occlusion, and he was treated with additional femoral artery stenting to secure the fracture site.


Sujets)
Sujet âgé , Humains , Mâle , , Artère fémorale , Récidive , Endoprothèses , Thrombose , Degré de perméabilité vasculaire
14.
Journal of the Korean Society for Vascular Surgery ; : 151-155, 2011.
Article Dans Coréen | WPRIM | ID: wpr-726650

Résumé

PURPOSE: Embolization of the internal iliac artery (IIA) is frequently required during endovascular aneurysm repair (EVAR) because of a concurrent common iliac artery aneurysm, a short common iliac artery, or deployment of aortouni-iliac devices. This study was conducted to evaluate the effectiveness of IIA embolization during EVAR. METHODS: A retrospective study was performed in patients undergoing EVAR and IIA embolization from December 2005 to March 2011 from a prospectively registered database of patients with aneurysms. Patient clinical characteristics, procedures, and follow up data were collected and analyzed. RESULTS: Eighteen patients (33.3%) required IIA embolization among 54 EVARs. The mean age was 73.5 years, and 17 patients were male. Indications were a common iliac artery aneurysm (11/18), short iliac artery (3/18), thrombosed common iliac artery (1/18), arteriovenous malformation (1/18), and deployment of aortouniiliac artery devices (1/18). One mortality occurred in a patient with a ruptured abdominal aortic aneurysm. No type I endoleaks were observed. IIA embolization was achieved with conventional coils (7/18), a vascular plug (6/18), and detachable coils (5/18). After EVAR, there were two cases of ileus, a limb occlusion that required additional stenting in the external iliac artery, a type II endoleak, and two cases of buttock claudication. CONCLUSION: IIA embolization during EVAR is effective to prevent a type II endoleak with minor morbidities.


Sujets)
Humains , Mâle , Anévrysme , Anévrysme de l'aorte abdominale , Artères , Malformations artérioveineuses , Fesses , Endofuite , Membres , Études de suivi , Iléus , Artère iliaque , Études prospectives , Études rétrospectives , Endoprothèses
15.
Journal of the Korean Society for Vascular Surgery ; : 184-189, 2011.
Article Dans Coréen | WPRIM | ID: wpr-726624

Résumé

Endovascular aneurysm repair (EVAR) has become prevalent and is expanding beyond conventional indications. A type I endoleak in the aortic neck is one of the main complications after EVAR, which limits long-term survival and requires immediate intervention. We experienced three cases of successful treatment of a type I endoleak after EVAR with adjunctive procedures and report them with a literature review.


Sujets)
Anévrysme , Anévrysme de l'aorte abdominale , Endofuite , Procédures endovasculaires , Cou
16.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 16-24, 2010.
Article Dans Coréen | WPRIM | ID: wpr-98600

Résumé

PURPOSE: Reactivation of hepatitis B virus (HBV) replication after hepatic resection might be a significant risk factor for prognosis in patients with chronic hepatitis B. The purpose of the present study was to investigate the changing pattern of serum HBV DNA titer after hepatic resection and to assess the incidence of reactivation of HBV replication. METHODS: Among HBV-positive patients who underwent hepatic resection for hepatocellular carcinoma, thirty-six patients with preoperative serum HBV DNA titer > or =3 log(10)copies/mL were enrolled. Serum DNA titers were examined before the operation, on the second and seventh postoperative days, and one month after the operation. RESULTS: The serum DNA titer decreased on the second postoperative day (p=0.078). The DNA level, however, had substantially returned to preoperative values by the seventh postoperative day (p<0.001). For most patients, the postoperative DNA titer reached its zenith on the seventh postoperative day or one month after the operation. The zenith level was higher (by 0.49+/-0.25 log10copies/mL) than preoperative levels although this difference just missed significance (p=0.068). Although postoperative reactivation of HBV replication emerged in 6 patients, only one of those patients developed postoperative hepatitis. Overall, four patients developed postoperative hepatitis and all of them had high postoperative HBV DNA levels (over 6 log(10)copies/mL). CONCLUSION: Although serum HBV DNA titers tended to increase postoperatively, routine antiviral therapy might be unnecessary because of the low incidence of postoperative hepatitis. High postoperative DNA levels, however, might be a risk factor for hepatitis, and postoperative follow-up of serum HBV DNA levels might be necessary in HBV-positive patients with hepatic resection.


Sujets)
Humains , Carcinome hépatocellulaire , ADN , Réplication de l'ADN , Études de suivi , Hépatectomie , Hépatite , Hépatite B , Virus de l'hépatite B , Hépatite B chronique , Incidence , Pronostic , Facteurs de risque
17.
Korean Journal of Radiology ; : 485-489, 2010.
Article Dans Anglais | WPRIM | ID: wpr-65177

Résumé

Although liver transplantation (LT) is the only effective treatment option for hepatopulmonary syndrome (HPS), the post-LT morbidity and mortality have been high for patients with severe HPS. We performed post-LT embolotherapy in a 10-year-old boy who had severe type I HPS preoperatively, but he failed to recover early from his hypoxemic symptoms after an LT. Multiple embolizations were then successfully performed on the major branches that formed the abnormal vascular structures. After the embolotherapy, the patient had symptomatic improvement and he was discharged without complications.


Sujets)
Enfant , Humains , Mâle , Association thérapeutique , Échocardiographie , Embolisation thérapeutique/méthodes , Syndrome hépatopulmonaire/diagnostic , Transplantation hépatique , Oxymétrie , Tomographie par émission de positons , Artère pulmonaire , Tomodensitométrie
18.
The Korean Journal of Hepatology ; : 168-175, 2010.
Article Dans Coréen | WPRIM | ID: wpr-14483

Résumé

BACKGROUND/AIMS: The follow-up strategy after hepatectomy for hepatocellular carcinoma (HCC) usually depends on the experience of physician, resulting in frequent imaging studies, which leads to increased cost. Hence, we investigated the role of monitoring alpha-fetoprotein (AFP) levels after hepatectomy in patients with preoperative high AFP. METHODS: From January 2000 to December 2004, 66 patients who underwent curative hepatectomy due to HCC with preoperative AFP level >400 ng/mL were reviewed. Changes in AFP level after the operation were investigated. The recurrence was suspected in case of two consecutive increase of AFP over cut-off value. Cut-off value was determined by ROC curve. All patients were divided into 2 groups: patients who met the definition (Group S) and those who didn't (Group D). RESULTS: AFP level of 20 ng/ml was proposed as the cut-off value for diagnosis of recurrence by ROC curve. Thirty two patients who didn't have the AFP level decreased below 20 ng/ml after the resection had HCC recurred, whereas 16 out of 34 patients who had AFP decreased had tumor recurrence. The AFP level of patients without recurrence was kept below 20 ng/ml during the follow-up. The AFP level of 44 out of 48 recurred patients increased over 20 ng/ml upon recurrence. By definition, group D were 5 patients. In 4 patients of group D, the AFP level didn't increase above 20 ng/ml upon recurrence. These patients had HCC and they recurred 1 year after the surgery. CONCLUSIONS: In patients with preoperative AFP level >400 ng/ml, the AFP level tended to increase above 20 ng/ml at recurrence mostly within 1 year. Hence, we proposed that these patients could be monitored by only AFP until 1 year after surgery.


Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Carcinome hépatocellulaire/mortalité , Survie sans rechute , Hépatectomie , Tumeurs du foie/mortalité , Récidive tumorale locale/mortalité , Courbe ROC , Alphafoetoprotéines/analyse
19.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 87-93, 2010.
Article Dans Coréen | WPRIM | ID: wpr-206300

Résumé

PURPOSE: To investigate the differentiation of rat bone marrow-derived mesenchymal stem cells (MSCs) into hepatocytes by cell transplantation using fibrin gels in a 70% hepatectomized rat model. METHODS: MSCs were isolated from Sprague-Dawley rats. MSCs (1.5x10(7) cells) were mixed with fibrin gels and injected immediately into the abdominal cavity of 70% hepatectomized rats. Fibrin-gels consisted of 500 IU/ml of thrombin and 90 mg/ml of fibrinogen. Transplanted MSCs in the fibrin scaffold were retrieved from surgically opened peritoneal cavities of rats on days 5, 10, 15, and 21 after the operation. The specimens were analyzed histologically and immunohistochemically. RESULTS: On H&E staining, MSCs from hepatectomized rats had changed to a round shape, while MSCs of the control group kept their spindle shape. When the fibrin matrix was biodegraded at day 15, the morphology of the MSCs had changed to hepatocyte-like cells without sinusoids and the hepatocyte-like cells had formed a three-dimensional tissue permitting cell-to-cell contacts within the matrix. On immunohistochemistry, MSCs expressed the hepatocyte markers cytokeratin 18, albumin, and alpha-fetoprotein, after 15 days of transplantation. CONCLUSION: When bone marrow-derived MSCs are transplanted using fibrin gels in the 70% hepatectomized rat, MSCs differentiate into hepatocyte-like cells and are conglomerated so that they form three-dimensional tissue-like hepatocytes without sinusoids.


Sujets)
Animaux , Rats , Cavité abdominale , Alphafoetoprotéines , Moelle osseuse , Différenciation cellulaire , Transplantation cellulaire , Fibrine , Fibrinogène , Gels , Hépatocytes , Immunohistochimie , Kératine-18 , Cellules souches mésenchymateuses , Rat Sprague-Dawley , Thrombine , Transplants
20.
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 235-241, 2009.
Article Dans Coréen | WPRIM | ID: wpr-140599

Résumé

PURPOSE: We wanted to evaluate the influence of preoperative non-surgical treatment and its duration for hepatocellular carcinoma (HCC) patients who underwent liver transplantation (LT). METHODS: We analyzed 75 patients with HCC who underwent living donor liver transplantation from January 1999 to December 2005. The median follow-up was 40.2 months. The patients were divided into the not treated group (26 patients) and non-surgically treated group (49 patients). We compared the overall survival (OS) and disease-free survival (DFS) rates of the 24 not treated patients with that of the 33 treated patients within the Milan criteria. The treated group was divided to 39 short-term ( or =3 years) treated patients by the preoperative treatment duration. The OS and DFS rates were analyzed. RESULTS: For 57 patients within the Milan criteria, the 1-, 3- and 5-year OS rates and the 1-, 3- and 5-year DFS rates were 80.0%, 68.5%, 64.8%, 82.0%, 77.2% and 75.1%, respectively. There were no different characteristic between the not treated group and the treated group, except for the mean age and the Child-Turcotte-Pugh score. Compared to the treated group, the OS and DFS rates were slightly better in the not treated group (p=0.053). There were more patients who underwent transcatheter arterial chemoembolization only in the short-term treated group and there were more patients who had microvascular invasion in the long-term treated group. The OS and DFS rates showed no significant difference between the two groups. CONCLUSION: It is possible that LT is a first treatment for HCC patients. If the patients' response to preoperative treatment was good, then their prognosis may be same regardless of the treatment duration.


Sujets)
Humains , Carcinome hépatocellulaire , Survie sans rechute , Études de suivi , Foie , Transplantation hépatique , Donneur vivant , Traitement néoadjuvant , Pronostic
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