Résumé
Sleep disorder, migraine, cognitive and behavioral disorders, anxiety and depression are common comorbidities of epilepsy. The comorbidity rate of epilepsy patients is eight times that of the general population, which affects the prognosis and quality of life of epilepsy patients. Perampanel (PER), as a third-generation antiseizure medication, has shown promising clinical research and application in the treatment of comorbidities in epilepsy. PER can improve the total sleep time, sleep latency and sleep efficiency of patients with epilepsy comorbid sleep disorder. PER also shows good efficacy in reducing seizure and migraine attacks of patients with epilepsy comorbid migraine. Meanwhile, the impact of PER on overall cognitive characteristics is neutral, with no systematic cognitive deterioration or improvement, but behavioral changes are one of the most common adverse events related to PER. For patients with comorbid anxiety and depression, PER does not exacerbate the anxiety and depression of epilepsy patients, and the severity of anxiety and depression in some patients will improve. This article will review the mechanism of action and clinical treatment research progress of PER on comorbidities of epilepsy.
Résumé
Objective To explore effective health education methods about diabetes mellitus and increase the health education qulity for patients with diabetes mellitus.Methods Patients with diabetes mellitus(192 cases)were divided into the test group and the control group with 96 cases in each group.The control group received routine health education.Health education pathway inventory was established for patients in the test group.The concrete aim of health education was considered and objective teaching method was used combined with clinical pathway.The health education effect was compared in the two groups.Results The excellent rate of health education knowledge and total satisfactory rate with nursing service in the test group was higher than that of the control group(P＜0.05).The blood slucose control in the test group Wag better than that of the control group(P＜0.05).Conclusion Objective teaching method combined with clinical pathway proved to be an effective health education method for diabetes mellitus.