Microwave mediated facile synthesis of some novel pyridine, pyrimidine, pyrazole, pyrazolo [1,5-a] pyrimidine and triazolo[1,5-a]pyrimidine pendant to pyrrole

The synthetic potency of E-3-[dimethylamino]-1-[1H-pyrrol-2-yl]prop-2-en-1-one towards some nitrogen nucleophiles was investigated under microwave irradiations as a convenient route for the synthesis of some novel pyridine, pyrimidine, pyrazole, pyrazolo [1,5-a] pyrimidine and Triazolo[1,5-a] pyrimidine derivatives

Conveninent synthesis and antimicrobial activity of pyrazolo [3,4-d] pyrimidine derivatives

Pyrazole derivatives 3a,b were formed upon reacting phenylhydrazine with ketene S, S-acetal or tetracyanoethylene. The pyrazole derivatives 3a, b were in turn used as precursors for the preparation of pyrazolo [3,4-d] pyrimidines which are expected to possess considerable chemical and pharmacological activities. The antimicrobial activity of the prepared compounds was tested

Oximes in heterocyclic synthesis: synthesis of ethyl 3-methyl-5-substituted isoxazol-4-carboxylate derivatives

Oxime of ethyl-3-oxobutanate [1] reacts with malononitrile and ethyl cyanoacetate to yield isoxazol derivatives [3a, b]. The products are further modified to new isoxazol and its fused derivatives. Oximes of beta-ketoesters and beta- oxonitriles are versatile magnets which have been used as substrates for the synthesis of heterocyclic compound [1-3] which are of potential biological activities [4-6]. This work was described to extent synthetic routs to new isoxazol derivatives using malononitrile and ethyl cyanoacetate as active methylene reagents in reaction with oxime of ethyl acetoacetate

Enaminonitrile in heterocyclic synthesis: synthesis of thiazolo [4,5-b] pyridine and thiazolo [4,5-d] pyrimidine derivatives

Ammoniumn- phenyldithiocarbamate reacted with bromomalononitrile and alpha chloroacetylacetone to afford thiazole derivatives 3a, b. Compound 3a reacted with benzylidenemalononitrile, malononitrile, phenylisothiocyanate, benzoylisothiocyanate, trichloroacetonitrile, formamide, carbon disulphide and triethylorthoformate to afford thiazolo [4,5-b] pyridine derivatives 6,9 and thiazolo [4,5-d] pyrimidine derivatives 13, 16, 18, 19, 20 and 21. Most of the synthesized products show high fungicidal and bactericidal activities