Résumé
Sujets)
Animaux , Humains , Souris , Graisse abdominale , Tissu adipeux , Cellules souches adultes , Phosphatase alcaline , Anesthésie locale , Biologie , Os et tissu osseux , Moelle osseuse , Régénération osseuse , Calcium , Durapatite , Test ELISA , Cellules souches mésenchymateuses , Souris nude , Microscopie de fluorescence , Ostéoblastes , Ostéocalcine , Ostéocytes , Ostéogenèse , Ostéopontine , Cellules souches , Cellules stromalesRésumé
Sujets)
Animaux , Rats , Os et tissu osseux , Moelle osseuse , Régénération osseuse , Hydrogels , Hydrogels , Cellules souches mésenchymateuses , Ostéoblastes , Ostéogenèse , Polyesters , Polyéthylène glycols , TransplantsRésumé
Maxillary sinus lift and bone graft are used to reconstruct atrophic maxilla molar area for endosseous dental implants. Many different grafting materials and techniques can be used for maxillary sinus bone graft. Bio-Oss(R) has been proposed as bone substitute and successfully utilized as osteoconductive filler. Platelet rich plasma (PRP) is an autologous material with many growth factors, such as PDGF, TGF-beta, IGF, VEGF, facilitating bone healing process. And Platelet poor plasma (PPP) is the by-product in procedure of producing PRP. Six rabbits were used as experimental animal. Both maxillary sinus were grafted with Bio-Oss(R) and PRP, and Bio-Oss(R) and PPP. Rabbits were sacrificed at 4, 8 and 12 weeks. The grafting sites were evaluated by histomorphometric analysis. As a result, using PRP showed excellent bone formation in the early stage, but no further significant effect after that. In late stage, the ability of bone formation of using PRP was even worse than using PPP. The further studies need to be considered in this case.