Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Acta Physiologica Sinica ; (6): 223-230, 2014.
Article Dans Chinois | WPRIM | ID: wpr-297497

Résumé

The phosphatidylinositol 3-kinase (PI3K) and its downstream target protein kinase B (Akt/PKB) can be activated by a variety of extracellular and intracellular signals. They are important signaling molecules and key survival factors involved in cell proliferation, differentiation, apoptosis and other cellular processes. Recently, many reports demonstrate that type I PI3K/Akt signaling pathway plays an important role in maintenance of self-renewal and pluripotency of embryonic stem (ES) cells. Further studies with regard to the self-renewal and pluripotency of ES cells and underlying molecular mechanisms are crucial to its application in cell replacement therapy, regenerative medicine and tissue engineering. The present review focuses on the recent progress on the mediation of PI3K/Akt signaling pathway on the maintenance of self-renewal and pluripotency of ES cells.


Sujets)
Humains , Différenciation cellulaire , Prolifération cellulaire , Cellules souches embryonnaires , Biologie cellulaire , Phosphatidylinositol 3-kinases , Physiologie , Cellules souches pluripotentes , Biologie cellulaire , Protéines proto-oncogènes c-akt , Physiologie , Transduction du signal
SÉLECTION CITATIONS
Détails de la recherche