RÉSUMÉ
Objective To study the relationship between serum interleukin‐17(IL‐17) ,acidophil cationic protein(ECP) ,immuno‐globulin E(IgE) and the severity of asthma .Methods A total of 84 patients with asthma were enrolled as asthma group ,who were divided into remission group and acute episode group .In addition to that 84 healthy persons were recruited as control group .The concentrations of serum IL‐17 ,ECP and IgE in different groups were compared .Results The concentrations of serum IL‐17 ,ECP and IgE in asthma group were statistically significantly higher than those in control group(P< 0 .05) .Among the patients with bronchial asthma ,serum levels of ECP and IgE in acute episode group were statistically significantly higher than those in remission group(P<0 .05) .There was positive correlation between serum ECP level and serum IgE level in asthma group(r=0 .432 ,P<0 .05) ,there was no significant correlation between serum IL‐17 level and serum levels of ECP and IgE ,but in acute episode group , serum IL‐17 level positively correlated with serum levels of ECP and IgE(r= 0 .327 ,0 .349 ,P< 0 .05) .Conclusion IL‐17 is in‐volved in mediating eosinophilic inflammation of asthma ,ECP and IgE levels have important clinical significances for predicting and treating asthma patients .
RÉSUMÉ
Objective To investigate the distribution and expression of trefoil factor 3(TFF3) in the eosinophilic cells and basophilic cells in the pars distalis of the rat pituitary .Methods The immunohistochemiscal staining technique was used to show the coexpression of TFF3/growth hormone (GH),TFF3/prolactin (PRL),TFF3/thyrotroph (TSH), TFF3/adrenocorticotropin (ACTH),TFF3/follicle stimulating hormone (FSH),TFF3/luteinizing hormone (LH) in two contiguous slices .Results The immunoreactive products of TFF 3 and chromophil cells were brown granules , mainly expressed in cytoplasm .ACTH positive signals were expressed in the cell membrane and mainly located in the pars distalis hypophyseos.TFF3 existed in parts of GH,PRL,TSH,ACTH,FSH and LH cells in contiguous slices, accounting for 19.4%, 22.4%, 9.2%, 6.5%, 35.7%, 8.3%, respectively , in which FSH was the most , PRL and GH were less . Conclusion TFF3 expresses in GH, PRL, TSH, ACTH, FSH, and LH cells in the pars distalis , which enriches the morphological data for the location of TFF 3 in gland cells of pars distalis hypophyseos .