Effects of bile acids and their related nuclear receptors on intestinal mucosal barrier / 中华肝胆外科杂志

Bile acids are the end product of cholesterol metabolism,which is the main component of bile.Bile acids can not only promote the absorption of fat and fat-soluble vitamins but also be used as the important signal molecules to activate nuclear receptors.It regulates metabolism of bile acids and intestinal homeostasis.The bile acids' effect on intestinal mucosal barrier function has been controversial until now.Bile acids is both hydrophilic and hydrophobic simultaneously.Hydrophilic bile acid can promote cell proliferation,while hydrophobic bile acid can promote cell apoptosis.The stronger the hydrophobicity is,the greater the cellular damage effect will be.The activation of nuclear receptor by bile acids can protect intestinal mucosal barrier.New research progress of the bile acid regulation in intestinal mucosal barrier function is reviewed in this article.

Research progress on the relationship between intestinal microbiota and bile acids / 国际儿科学杂志

Intestinal microbiome is a popular research field nowadays,which is involved in many kinds of metabolism and has significant relationship with many diseases in human.Gut microbiota is a part of microbiome and one of the guarantee of human health.Bile acid is an important digestive enzyme participating in the digestion and absorption of food.It is produced by the liver and enter the small intestine through the biliary systern.In recent years,many studies have shown that there are the closely related between the gut microbiota and bile acid.On the one hand,gut microbiota can encode a variety of enzymes,such as bile salt hydrolase and 7α-dehydroxylate,to effect the metabolism of bile acids and change the composition of bile acid pool.Bile acid pool,on the other hand,as a generic term of all kinds of bile acid,can directly inhibit the activity of bacteria or have indirect influence through regulating the intestinal barrier function on the distribution and growth of bacteria.Bile acids can also limit the overgrowth of pathogenic bacteria such as Clostridium difficile.This review,Summarizes the relationship between the gut microbiota and bile acid.