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Indian J Hum Genet ; 2013 July-Sept ;19 (3): 342-345
Article Dans Anglais | IMSEAR | ID: sea-156588

Résumé

OBJECTIVES: The objective of this study is to determine the inheritance pattern of type‑2 diabetes and make stratification for the general population risk. MATERIALS AND METHODS: A questionnaire was developed for o btaining the family history. Analysis of the data was carried out by using student and Chi‑square tests and for stratification; the guidelines of Scheuner et al. were followed. RESULTS: The pattern of inheritance is the male sex specific (χ² =13.44). The mean age of onset of diabetes in parents was 58.61 ± 2.94 and in offspring 46.75 ± 2.54. In all 47.22 ± 11.53% families were found in high risk and 31.94 ± 10.77% in the moderate risk category. In female diabetics, the onset was in the age range of 41‑60 years. CONCLUSION: We found a high‑risk of diabetes and familial clustering in successive generations of Brahmins with prominent male sex specificity. In females onset of diabetes was coinciding with the period around menopause.


Sujets)
Adulte , Diabète de type 2/analyse , Diabète de type 2/épidémiologie , Diabète de type 2/génétique , Famille/histoire , Femelle , Humains , Inde/épidémiologie , Modes de transmission héréditaire/génétique , Prévalence , Groupes de population/génétique , Groupes de population/histoire , Appréciation des risques
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