RÉSUMÉ
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy, characterized by late diagnosis, aggressive growth, and therapy resistance, leading to a poor overall prognosis. Emerging evidence shows that the peripheral nerve is an important non-tumor component in the tumor microenvironment that regulates tumor growth and immune escape. The crosstalk between the neuronal system and PDAC has become a hot research topic that may provide novel mechanisms underlying tumor progression and further uncover promising therapeutic targets. In this review, we highlight the mechanisms of perineural invasion and the role of various types of tumor innervation in the progression of PDAC, summarize the potential signaling pathways modulating the neuronal-cancer interaction, and discuss the current and future therapeutic possibilities for this condition.
Sujet(s)
Humains , Carcinome du canal pancréatique/anatomopathologie , Tumeurs du pancréas/thérapie , Transduction du signal , Nerfs périphériques/métabolisme , Microenvironnement tumoralRÉSUMÉ
With the development of oncology and neuroscience, cancer-neuroscience, as their interdisciplinary subject, has also attracted widespread scholars' attention in recent years. People have gradually realized that neurons are involved in the formation of tumor microenvironment and affect the initiation and progression of tumor. Similarly, tumor can also cause nervous system remodeling and dysfunction. The relationship between glioma, as the most common malignant tumor in the central nervous system, and neurons have gained a new understanding. This review discusses the latest advance in cancer-neuroscience in the study of gliomas, and systematically reviews the mechanism of interaction between neurons and glioma cells.