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Braz. j. microbiol ; 40(4): 980-987, Oct.-Dec. 2009. tab
Article Dans Anglais | LILACS | ID: lil-528188

Résumé

The postantibiotic effects (PAEs) and postantibiotic sub-MIC effects (PA SMEs) of tilmicosin, erythromycin and tiamulin on erythromycin-susceptible and erythromycin-resistant strains of Streptococcus suis (M phenotype) were investigated in vitro. Tilmicosin and tiamulin induced significantly longer PAE and PA SME against both erythromycin-susceptible and erythromycin-resistant strains than did erythromycin. The durations of PAE and PA SMEs were proportional to the concentrations of drugs used for exposure. The PA SMEs were substantially longer than PAEs on S. suis (P<0.05) regardless of the antimicrobial used for exposure. The results indicated that the PAE and PA SME could help in the design of efficient control strategies for infection especially caused by erythromycin-resistant S. suis and that they may provide additional valuable information for the rational drug use in clinical practice.


Sujets)
Animaux , Antibactériens/analyse , Antibactériens/effets indésirables , Prédisposition aux maladies , Résistance microbienne aux médicaments , Techniques in vitro , Infections à streptocoques , Suidae , Streptococcus suis/croissance et développement , Streptococcus suis , Streptococcus suis/génétique , Streptococcus suis/isolement et purification , Milieux de culture , Méthodes , Phénotype , Réaction de polymérisation en chaîne/méthodes , Études par échantillonnage , Méthodes
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