Superficial Angiomyxoma of the Eyelid. A Case Report and Review of the Literature

@#Superficial angiomyxoma (SA) is an angiomyxoid cutaneous tumour. It has predilection for the head and neck, torso, limbs and genital tract. Our case is a 27-year-old female, presented with painless right medial canthal mass for two years. It was associated with tearing when the lesion grew larger. We received a nodular brownish tissue measuring 25x20x15mm with homogenous brownish cut surface. Microscopically, the tumour was partially circumscribed, exhibiting bland stellate to spindle cells of moderate cellularity with pale eosinophilic cytoplasm, indistinct border, in a loose collagenous myxoid matrix with numerous blood vessels of different calibre. The lesional cells were present at the resected margin and were nonreactive towards CD34, SMA and S100. SA of the eyelid is sometimes mistaken clinically as dermoid cyst or lipoma. Reports have shown increased risks of local recurrence following incomplete excision. Close association with Carney’s complex is an important feature. Careful clinicopathologic correlation and proper investigations are needed for optimal patient care.

Novel Mutation in PRKAR1A in Carney Complex

A case of Carney complex in a Korean patient is presented. The patient had the characteristics of Carney complex including skin lesions, positive family history, and multiple myxomas including a superficial angiomyxoma in the perianal area. An extensive genetic analysis revealed a novel mutation in the protein kinase A type I-a regulatory subunit (PRKAR1A) gene, but not in the phosphodiesterase type 11A (PDE11A) gene. This is the first case wherein extensive genetic studies were performed in a patient with Carney complex in Korea.

An Atypical Giant Angiomyxoma with Multiple Superficial Angiomyxomas / 대한피부과학회지

Superficial angiomyxoma (SAM), often referred to as cutaneous myxoma, is a rare benign myxoid tumor of soft tissue. It commonly manifests as a single mass, but is occasionally detected as multiple tumors in Carney's complex. Nowadays, however, SAM is regarded as an independent cutaneous tumor regardless of whether Carney's complex is present. SAM occurs most commonly on the trunk, limbs, head, and neck. Herein we report a rare case involving a 21-year-old woman who presented with multiple tumors consisting of a single giant pedunculated mass surrounded by multiple nodules on her left labium major. Histological analysis revealed that the tumors were composed of widely scattered bland spindle-shaped or stellate cells with ill-defined cytoplasm and variably sized vessels within a basophilic myxoid stroma. The tumors were completely removed by total excision and primary closure with an excellent cosmetic outcome.

A Case of Solitary Superficial Angiomyxoma / 대한피부과학회지

Solitary superficial anigomyxoma, sometimes referred to as solitary cutaneous myxoma, is a relatively uncommon benign myxoid tumor of soft tissue. Clinically, the lesions present on the head, neck or trunk of adults as slowly-growing, solitary, asymptomatic nodules or polyps ranging in size from 1 to 5 cm. Histologically, solitary superficial angiomyxoma consists of ill defined, basophilic myxoid lobules containing bland spindle-shaped or stellate cells and abundant small blood vessels in the dermis, frequently involving subcutaneous fat. We herein report a case of solitary superficial angiomyxoma which developed in the auricular concha of a 31-year-old man.

A Case of Solitary Superficial Angiomyxoma / 대한피부과학회지

Solitary superficial angiomyxoma gap (SSA), sometimes referred to as solitary cutaneous myxoma, is a relatively uncommon benign myxoid tumor of soft tissue. It is characterized clinically by slowly-growing, asymptomatic nodules on the head, neck, and trunk of adults. It is locally recurrent, but there have been no reports of metastatic spread. Histologically, SSA consists of the conglomerate of moderate-to-sparse cellular angiomyxoid nodules with scattered, small to medium-sized blood vessels in the dermis, frequently involving subcutaneous fat. We herein report a case of SSA which developed in the genital area of an 80-year-old woman.

A Case of Solitary Superficial Angiomyxoma / 대한피부과학회지

Solitary superficial angiomyxoma gap (SSA), sometimes referred to as solitary cutaneous myxoma, is a relatively uncommon benign myxoid tumor of soft tissue. It is characterized clinically by slowly-growing, asymptomatic nodules on the head, neck, and trunk of adults. It is locally recurrent, but there have been no reports of metastatic spread. Histologically, SSA consists of the conglomerate of moderate-to-sparse cellular angiomyxoid nodules with scattered, small to medium-sized blood vessels in the dermis, frequently involving subcutaneous fat. We herein report a case of SSA which developed in the genital area of an 80-year-old woman.

Superficial Angiomyxoma: A case report

Superficial angiomyxoma is a comparatively rare dermal and subcutaneous tumor. We report a case of superficial angiomyxoma of the thumb in view of its rarity and typical light and electronmicroscopic features. The patient was a 46-year-old male. who presented with an asymptomatic, slowly enlarging mass that developed in the left thumb over the 5 years. He had a history of trauma and electric burn in the same area 20~30 years ago. Simple X-ray and magnetic resonance imaging revealed 35x30mm, mass with destruction of distal phalangeal bone. On operation, the lesion was moderately well circumscribed and soft with lobulated nodules that elevated the overlying skin and destroyed the underlying bone. The cut surface of the mass was glistening and slimy. The mass was whitish gray and lobulated. Bony involvement was not present. Microscopically, the tumor was composed of stellated and spindle shaped stromal cells which were scattered throughout myxoid ground substance. Neither nuclear hyperchromasia nor plemorphisam was present. Small to medium sized thin walled blood vessels were scattered. There was a scanty infiltrate of inflammatory cells. The S-100 protein immunostaining was negative in tumor cells. On electron microscopy, the cytoplasm of the stromal cells contained well developed rough ednoplasmic reticulums and other features that indicated differentiation toward fibroblasts.