Review on Plants Used in Siddha Formulation Vatha Siletpana Sura Kudineer for the Management of Viral Fever

Siddhars said about various diseases and the treatment methods with herbs, minerals and animal products. In Siddha literatures viral fevers can be compared to Vatha Kapha Suram and therefore decoction for this Suram is taken from classical Siddha text book and the ingredients are searched for pharmacological activity and toxicity study from 118 published journal papers from Pubmed, Scopus, Google Scholar, Research Gate and Science Direct. Collected data is entered in MS excel and analysed using RFC score. All together there are 51 pharmacological activities are published for these nine ingredients. In which Anti-inflammatory has RFC=1, other properties like antipyretic, anti-tussive, bronchodialator, anti-asthmatic, analgesic, neuro-regenerative, neuroprotective, anti-diarrhoeal, anti-emetic, neuroprotective, analgesic, sedative has more than 0.55 RFC score. More than this cardioprotective, renoprotective, hepatoprotective, and other protective properties are present in more than 50% of ingredients. In toxicity studies no toxic effects are seen in in vivo studies for the ingredients The Suvai, Thanmai, Pirivu, in Siddha aspect, of these ingredients can highly reduces Vatha and Kapha disorders. Therefore, the decoction shows significant pharmacological activity for the sign and symptoms of viral infections.

Aetiological profile of fever in neonatal and paediatric population in hospital setting

Background: Febrile illness in children is a common cause of admission to hospital globally, with significant associated morbidity and mortality. Dengue, malaria, scrub typhus, typhoid and leptospirosis have been identified as major causes of acute undifferentiated febrile illness in Thailand, Malaysia, and Nepal. Climate variation, over population and urbanization may all contribute to the emergence and reemergence of infections in tropical regions like Tamil Nadu. The objectives of this study were to describe the aetiology of fever in hospitalized neonatal and Pediatric population. A descriptive study was designed.Methods: A prospective observational study was conducted. All children from 0 to 18 years admitted as in-patients. Sample size was calculated to be 650. Basic laboratory tests were done in all cases.Results: Out of a total of 650 children maximum number (40.7% n=265) of patients had short duration of fever between 1 to 3 days. Majority (56%) of patients had temperature between 100.4 to 101F. Only 5 children were confirmed to have malaria. Maximum number of pus cells found was 80 to 100 in 3 children in urine examination. Total Infectious cases were 631 (97.07%).Conclusions: Infectious aetiology was more common than non-infectious aetiology. Among all aetiologies, viral fever particularly dengue was the most common aetiology. Enteric fever was the second most common infectious cause of fever after viral fever.' Short febrile illness (1 to 5 days) was the most common type of fever in children admitted in hospital. In neonates, the most common cause of fever was probable sepsis followed by dehydration fever.

Efficacy and Safety of Cloud based Continuous Monitoring Systems in Management of Patients in Non-ICU Settings in a Tertiary Care Hospital

Introduction: Continuous monitoring is the most vital aspect in the management of patients in non-ICU settings. Continuous monitoring systems have revolutionized the management of vulnerable patients which alerts the doctors to identify the critical events and intervene timely. In this study, we present our experience of using cloud connected continuous monitoring systems at our hospital. Objectives: To study the efficacy and safety of continuous monitoring systems in the management of patients in a non-ICU setting. Material and methods: A retrospective hospital-based study was conducted in the Acute Medicine ward (AMW) of Ramaiah teaching Hospital, Bangalore. Patients were connected to a cloud based continuous monitoring system for automatic collection and documentation of vital signs. All patients admitted in AMW between September 2017 and January 2018 was included in the study. For comparison, data were collected from September 2016 to January 2017 when the continuous monitoring systems were not implemented. We compared the number of admissions, code blue events. Results: Total of 470 patients in the pre- ICU settings were connected to a continuous monitoring system. There was 88% reduction in the ICU admissions as compared to the previous year. About 11.2% of patients were transferred to ICU and in these patients, continuous monitoring helped the doctors to identify the critical event. There was a significant reduction in code blue events using a continuous monitoring system. There was a significant reduction in medical expenses also. Conclusion: Continuous monitoring reduced the clinical burden on ICU due to the availability of remote monitoring capabilities, and continuous monitoring of reduced medical expenses for patients with improved clinical outcomes.

Thrombocytopenia in children: a clinico-etiological profile in an urban tertiary care hospital

Background: Thrombocytopenia is a common haematological finding that we come across while managing a sick child. Etiological profile and presentation of thrombocytopenia varies among children. The objective of this study was to study the clinical and laboratory profile of children with thrombocytopenia, associated clinical complications and assess the relationship between platelet levels and severity of disease.Methods: The study was carried out in 644 children between 1 month and 12 years, admitted in Paediatric Department of Raja Rajeshwari medical college and hospital, Bangalore between August 2012 to August 2014.Results: The commonest causes of thrombocytopenia in our study were of infectious aetiology (86.6%). Among Infections Viral infections were the major cause in more than 78% of cases. Other causes included haematological problems, drug induced thrombocytopenia and connective tissue disorders. Bleeding manifestations were present in 33.07% of patients and the commonest bleeds were skin and mucous membranes. Bleeding manifestations were seen most commonly in children with a platelet count less than 50000/'l.Conclusions: Viral Infections were the commonest cause for thrombocytopenia in Children. Platelet count was neither predictive of bleeding manifestations nor predictive of need for platelet transfusion.

A Clinical Study on Thrombocytopaenia in Viral Fevers and Malaria

Background:Thrombocytopaenia, decrease platelate count is seen in many viral fevers including heptitis 'C', HIV infections and malaria which is very comman in developing countries.[1] In Thrombocytopaenia due to viral Haemorrhagic fever, others features like increased haematocrit, leucopenia will present along with Thrombocytopaenia. Automated quatitative D3 analysis is used to detect Thrombocytopaeniain our study the commonest causes of Thrombocytopaenia is vivax malaria. Aims and Objectives: This study is to evaluate the Thrombocytopaenia as diagnostic and prognostic tool in viral fevers and malaria. Methods: In our study we have examined 200 patient’s acute febrile illness out of these 200 patients, 10 were diagnosed as dengue fever, 100 were diagnosed as Malaria. Thick and thin blood fever slides were prepared and examined by pathologist. Results: Out of 200 patients 110 were diagnosed as Malaria, 10 patients were diagnosed as Dengue fever Thrombocytopaenia is observed in 60 patients. Conclusion: Thrombocytopaenia is common in viral fevers and Malaria. After exclusion of dengue fever, malaria should be considered in all the patients with low platelet counts.

Fiebre amarilla: a propósito de la alerta / Yellow Fever: a reason to be alert

La infección por el virus de la fiebre amarilla es una fiebre hemorrágica aguda inmunoprevenible, potencialmente peligrosa a viajeros no vacunados en áreas enzoóticas, con una elevada mortalidad en los casos sintomáticos. El arbovirus es transmitido en un ciclo involucrando primates y mosquitos, pero el ser humano puede ser utilizado como huésped intermediario. Durante el año 2003, Colombia reportó a la Organización Panamericana de la Salud (OPS) 106 casos de fiebre amarilla selvática1. En las primeras semanas del 2004 se notificaron en ciudades consideradas centros turísticos, con altos índices de infestación por Aedes aegypti, unidos a factores como los problemas sociales y de conflicto armado en la región, lo cual representa un alto riesgo de urbanización de la enfermedad. Estas circunstancias ponen de manifiesto la importancia de mantener una vigilancia activa para impulsar medidas de prevención y control integrales que permitan anticiparse a situaciones de mayor gravedad. El Ministerio de Salud se encuentra vacunando masivamente a la población de las áreas afectadas, con el fin de controlar la epidemia. Fundamentado en ésta alerta epidemiológica nacional, hace una revisión teórica de la información clínica, diagnostica y tratamiento disponible para el manejo de la Fiebre Amarilla.

The infection by the virus of the Yellow Fever is an immunological, as well as a preventable acute hemorragic febrile syndrome, which is potentially dangerous to non-vaccinated travellers in zoonotic areas, presenting high mortality among symptomatic cases. Arbovirus is transmitted through a cycle involving primates and mosquitos, but humans act as an intermediary guests. During the year 2003, Colombia reported to the Pan-American Organization of Health (OPS) 106 cases of the jungle yellow fever. In the first weeks of the 2004 new cases were notified to Tourist Centers in many cities, with high indices of infestation by Aedes aegypti, together with factors like the social problems and armed conflict ever present on those regions. This situation represent a high risk for the disease to become urban. These circumstances show the importance to keep a close monitoring to implement tough measures for prevention and control, in order to anticipate serious situations. Nowdays The Colombian Ministry of Health is involved in massive vaccination programs among people in affected areas. Taking in consideration this epidemiological alert we have decided to conduct a medical review of the clinical information, as well as, its diagnosis and its best possible treatment for the Yellow Fever.