Résumé
With advanced brewing technology and contemporary table culture， alcohol drinking， which can be traced back to Dukang wine in the Xia dynasty， is very common in China. However， excessive alcohol intake can easily cause alcohol liver damage， ranging from abdominal pain and venous thrombosis to severe hypoglycemia and fat embolism， coma shock and even life-threatening cases. Puerariae Lobatae Radix has a cool property and sweet taste， with functions of antipyretic， promoting the secretion of saliva or body fluid， rash and hangover alleviation， and so on. It was first recorded in Shen Nong's Materia Medica and has been listed as a special anti-alcoholic medicine in traditional Chinese medicine since ancient times. For example， the ancient medical book Compendium of Materia Medica and other records claim that Puerariae Lobatae Radix has the effect of relieving alcohol and protecting the liver. At the same time， Puerariae Lobatae Radix has a long history in both medicine and food. It was listed in the List of Articles That Both Serve as Food and Medicine published by the National Health Commission. Therefore， there are many products containing pueraria for hangover and liver protection. Prior to this， many scholars have carried out relevant researches on the anti-alcoholism efficacy of Puerariae Lobatae Radix， but there is a lack of systematic summaries. The author has consulted relevant domestic and foreign literatures in recent years. The related products were summarized and it was found that the anti-alcoholic effect of pueraria root mainly came from puerarin， pueraria flavonoids and pueraria polysaccharide， puerarin polypeptide， pueraria daidzein and its derivatives， including the main mechanisms such as inhibiting alcohol absorption， accelerating metabolism， anti-oxidation， protection of liver and cardiomyocytes， and neuroprotection. Related products are abundant and well evaluated， but research on related genes needs to be deepened. This article reviews the main anti-alcoholic components， mechanism of action and related products of pueraria， and puts forward suggestions for future research directions， hoping to provide reference for further related research.
Résumé
OBJECTIVE:To study on the effect of ethyl acetate extract of the seeds of Semem Hoveniae.against alcoholism.METHODES:The mice were divided into four groups:model group(i.g.normal saline),positive group(i.g.Haiwangjinzun 20 g?kg-1),low-dose group of ethyl acetate extract(i.g.ethyl acetate extract 10 g?kg-1),and high-dose group of ethyl acetate extract(i.g.ethyl acetate extract 20 g?kg-1).The effects of different extracts on serum SGPT activity,MDA content and ADH activity,GSH content and SOD activity in liver tissue of mice with acute alcoholism were determined.RESULTS:Serum SGPT activity and MDA content were down-regulated while ADH activity,GSH content and SOD activity in liver tissue of acute alcoholism mice were up-regulated by the ethyl acetate extract of the seeds of Hovenia Dulcis Thunb.CONCLUSION:The ethyl acetate extract of the seeds of Semem Hoveniae exhibited remarkable anti-alcoholism efficacy,and which is worthy of further study.