RÉSUMÉ
Objective To discuss the expression and clinical significance of telomerase and hTERT in ovarian neoplasm tissues . Methods The activities of telomerase and the expression levels of hTERT mRNA were detected in the tissues of malignant ovarian neoplasm ,benign ovarian neoplasm and normal ovarian respectively ,and the results were analyzed .Results Comparing with the tis‐sues of benign ovarian neoplasm and normal ovarian ,the activity of telomerase and the expression level of hTERT mRNA increased in malignant ovarian neoplasm tissues ,and the differences were statistically significant(P< 0 .05) .Conclusion The telomerase plays an important role in the occurrence and development of malignant ovarian neoplasm .The detection of telomerase activity can help in early diagnosis of malignant ovarian neoplasm .
RÉSUMÉ
Purpose:To explore the role of terminal restric tion fragments (TRFs), telomerase activity and expression of human telomerase re verse transcriptase (hTERT) in colorectal carcinoma. Methods:The telomere length, telomerase activity and expression of hTERT were studied with Southern-blot, TRAP and immunohistochemistry, respe ctively. Results:TRFs in cancer tissue was much shorter than in the adja cent tissues and normal mucosa, and TRFs was decreased gradually along with the development in cancer stage.The expression of Telomerase in colorectal carcinoma tissue was significantly higher than that in other tissues (P