RÉSUMÉ
Objective: To study the discharge changes of CA1 area place cells after hippocampal formation (HF) accepting the visua--vestibular-proprioceptive mismatch configuration as a match by learning, so as to provide evidence that HF may encode any combination of sensory inputs. Methods: The visual-vestibular-proprioceptive mismatch configuration was set up. According to θ rhythm recording and θ power calculation in rat hippocampal dentate gyrus, adaptation to the sensory conflict could be confirmed. The assembly discharge of CA1 area place cells was recorded in awake rats by using extracellular tungsten microelectrode record and stereotaxic techniques after the ratsa dapted to sensory mismatch. Results: Of the 56 place cells, 14 (25.0%) showed consistent spatial firing in both the match and mismatch conditions (bi-directional movement-related experience-independent neurons); 33 (58.9%) showed different spatial firings across the sessions (bi-directional movemen--related experience-dependent neurons). The mean sizes and mean value of index of asymmetry of the place fields were larger in bi-directional movement-related neurons than that in experience-dependent neurons (P<0.01, P<0.05). The firing rate distributions in the place fields were negatively skewed and asymmetric. Conclusion: The HF encodes a naturally impossible new configuration of sensory inputs after adaptation, and it can update the stored memory to accept a new configuration as a match. The HF may encode any combination of sensory inputs.
RÉSUMÉ
Objective To observe the effects of interleukin-1 ?(IL-1?) on spontaneous electrical activity of neurons in paravenrticular nuclei,and discuss the possible mechanism.MethodsExtracellular recording technique was employed to observe the effects of IL-1? on spontaneous electrical activity of neurons in paravenricular nuclei in rat hypothalamic slices,and the influence of losartan on the electrical activity induced by IL-1? was examined.ResultsAfter exposure to IL-1?(1?10-7 mol/L),the discharge frequency was significantly increased in 46 of the 59 discharge units(78%) of neurons(P