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Acta Pharmaceutica Sinica ; (12): 662-665, 2006.
Article Dans Chinois | WPRIM | ID: wpr-294963

Résumé

<p><b>AIM</b>To isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.</p><p><b>METHODS</b>Various column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.</p><p><b>RESULTS</b>One compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.</p><p><b>CONCLUSION</b>2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.</p>


Sujets)
Humains , Antibactériens , Chimie , Pharmacologie , Antinéoplasiques , Chimie , Pharmacologie , Bacillus subtilis , Lignée cellulaire tumorale , Survie cellulaire , Fermentation , Composés du fer III , Chimie , Pharmacologie , Ferrichrome , Chimie , Pharmacologie , Deuteromycota , Chimie , Structure moléculaire , Peptides cycliques , Chimie , Pharmacologie , Récepteurs à l'interleukine-6
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