Effect of cortisone administration on the histological structure and lipid content of mouse adrenal cortex

After a single IM injection of cortisone, the adrenal glands of 9 male mice were taken at different periods of time [3 hours, 2 days and 3 days, 3 at a time]. The histological structure and lipid content have been studied. The results obtained in the present study showed marked narrowing of the adrenal cortex compared to the medulla. This narrowing involved only zona fasciculata and zona reticularis. Zona glomerulosa, however, showed relative broadening in width. Depletion of sudanophilic materials initially occurred followed by a marked increase 2 days after injection

Effect of anoxia and heat on the histological structure and lipid content of mouse adrenal cortex

Nine male mice were included in the present study. They were kept in individual small cages in an oven of constant temperature at 45C, with low oxygen content, then the adrenal glands were taken at different periods of time [5, 10 and 15 minutes]. The histological changes and lipid content have been studied. The results obtained indicated that heat exposure with anoxia showed fast and severe changes within 10 minutes of time. Marked dilatation of blood sinusoids was observed, extending deeply to the outer zona fascicualata. Most of the zona fasciculata was initially occupied by clear cells which later on changed to be compact. Patchy loss of the subglomerlosal zone was seen. Gradual lipid depletion occurred after 10 minutes of exposure to heat and anoxia