Sujets)
Humains , Immunothérapie adoptive/méthodes , Lymphome B diffus à grandes cellules/thérapie , Leucémie-lymphome lymphoblastique à précurseurs T/thérapie , Récepteurs chimériques pour l'antigène/usage thérapeutique , Immunothérapie adoptive/instrumentation , Immunothérapie adoptive/tendances , Lymphome B diffus à grandes cellules/immunologie , Leucémie-lymphome lymphoblastique à précurseurs T/immunologie , Récepteurs chimériques pour l'antigène/synthèse chimiqueRésumé
Human immunodeficiency virus (HIV) infection is a risk factor for developing non-Hodgkin's lymphoma. Most acquired immune deficiency syndrome (AIDS)-related lymphomas are high-grade B cell non-Hodgkin's lymphomas. The use of highly active antiretroviral therapy has reduced the incidence of AIDS-related lymphoma. There have been 7 reports of AIDS-related extra-nodal lymphoma in Korea. We report a case of AIDS-related lymphoma detected by MiroCam(R) capsule endoscopy.
Sujets)
Humains , Mâle , Adulte d'âge moyen , Syndrome d'immunodéficience acquise/complications , Agents antiVIH/usage thérapeutique , Thérapie antirétrovirale hautement active , Capsules vidéo-endoscopiques , Infections à VIH/virologie , Tumeurs du jéjunum/diagnostic , Lymphome lié au SIDA/diagnostic , Lymphome B diffus à grandes cellules/immunologie , TomodensitométrieRésumé
AIM: To determine EBNA-1 expression in the tissue of patients with diffuse large B-cell lymphoma and its relationship to bcl-2 expression. METHODS: Paraffin-embedded tissue from 24 cases of diffuse large B-cell lymphoma were stained immunohisto chemically with monoclonal antibody anti-EBNA-1 and anti-bcl-2 using Streptavidin Biotin Complex method. The bcl-2 expression was measured as negative (no staining), positive 1 (weak staining), and positive 2 (moderate to strong staining). The relationship between the immunohisto chemistry results was examined. RESULTS: From the 24 samples, 12 (50%) were EBNA-1 positive and 14 (58.3%) showed expression of bcl-2. Eleven of the 14 samples (90%) showed expression of bcl-2 were EBNA-1 positive, while only 3 of these samples (10%) were EBNA-1 negative. The relationship between bcl-2 expression and EBNA-1 was statistically significant (Chi square-uncorrected 11.2571, p= 0.0036). CONCLUSION: Our results showed that 50% of diffuse large B-cell lymphoma were EBNA-1 positive. Furthermore, EBNA-1 seemed to be correlated with bcl-2 expression.
Sujets)
Adulte , Sujet âgé , Études transversales , Antigènes nucléaires du virus d'Epstein-Barr/métabolisme , Femelle , Humains , Immunohistochimie , Lymphome B/immunologie , Lymphome B diffus à grandes cellules/immunologie , Mâle , Adulte d'âge moyen , Protéines proto-oncogènes c-bcl-2/métabolismeRésumé
E método de inmunofijación simplificado ha resultado útil en la identificación de anormalidades monoclonales no caracterizadas por inmunoelectroforesis. Este métodos permitió resolver 3 de 19 muestras de suero procesados, con una alteración monoclonal no caracterizada completamente por inmunoelectroforesis. Basados en estos resultados y en la revisión de la literatura, se propone el método de inmunofijación simplificado para la identificación y caracterización de anormalidades monoclonales, cuando éstas no son satisfactoriamente clasificadas por inmunoelectroforesis