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Indian J Exp Biol ; 2001 Jan; 39(1): 47-51
Article Dans Anglais | IMSEAR | ID: sea-59413

Résumé

Effect of penetration enhancers were studied on the permeation of antihypertensive drugs prazosin hydrochloride and atenolol through full thickness skin of swiss albino mice. Atenolol was delivered to skin from saturated alcoholic solution containing 5% of 1-decanol and alcohol alone, while prazosin hydrochloride was saturated in dimethyl formamide(DMF, 5% v/v in water) and dimethyl sulfoxide(DMSO, 5% v/v in water). Atenolol permeation was augmented significantly in decanolic solution and also in pure alcohol. In case of prazosin hydrochloride, significant enhancement of permeation was shown by DMSO but not by DMF.


Sujets)
Administration par voie cutanée , Animaux , Aténolol/administration et posologie , Diméthylsulfoxyde/administration et posologie , N,N-Diméthyl-formamide/administration et posologie , Éthanol/administration et posologie , Alcools gras/administration et posologie , Souris , Prazosine/administration et posologie , Absorption cutanée/effets des médicaments et des substances chimiques
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