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EMHJ-Eastern Mediterranean Health Journal. 2007; 13 (2): 257-265
Dans Anglais | IMEMR | ID: emr-156993

Résumé

To address the role of the opioid system in the pathogenesis of hepatic encephalopathy [HE] we measured plasma met- enkephalin, beta -endorphin and leu- enkephalin in patients with different grades of HE compared to control subjects and patients with cirrhosis. Plasma met- enkephalin levels were significantly higher in patients with cirrhosis and all grades of HE than controls. Plasma beta levels were similar in the 3 groups. Plasma leu- enkephalin levels were significantly higher -endorphin in HE grades II, III and IV than in controls, patients with cirrhosis and HE grade I patients. Our results support data on the involvement of met- enkephalin and leu- enkephalin in the pathogenesis of HE and provide a rationale for the use of opioid receptor antagonists in the treatment of HE


Sujets)
Femelle , Humains , Mâle , Encéphalopathie hépatique/physiopathologie , Méthionine-enképhaline/sang , Leucine-enképhaline , Peptides opioïdes/sang , bêta-Endorphine/sang , Tests de la fonction hépatique
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