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An. acad. bras. ciênc ; 89(1,supl): 635-647, May. 2017. tab, graf
Article Dans Anglais | LILACS | ID: biblio-886672

Résumé

ABSTRACT The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI: GD 9, 91/2 or 10; DBA/2J: GD 10 or 101/2). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar -with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted.


Sujets)
Animaux , Femelle , Grossesse , Rats , Squelette/malformations , Tératogènes/toxicité , Somites/malformations , Développement embryonnaire/effets des médicaments et des substances chimiques , Embryon de mammifère/malformations , 1-Méthyl-1-nitroso-urée/toxicité , Squelette/effets des médicaments et des substances chimiques , Squelette/embryologie , Somites/effets des médicaments et des substances chimiques , Somites/embryologie , Embryon de mammifère/effets des médicaments et des substances chimiques , Souris de lignée DBA
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