Résumé
Six compounds were isolated from Monsonia nivea Decne. Webb. [Geraniaceae] growing in Egypt. The compounds are sterol, triterpene and flavonoid in nature. These compounds were identified as alpha-amyrin, beta-sitosterol, ursolic acid, apigenin-7-O-beta-D-glucopyranoside, quercetin-3-O-glucoside and rutin. The structures of the isolated compounds were confirmed by different spectroscopic methods. The anti-oxidant, anti-bacterial and the DNA-binding activities [as an indicator for anti-tumor activity] were carried out for the extracts and some pure compounds
Sujets)
Préparations à base de plantes/isolement et purification , Stérols/composition chimique , /composition chimique , Flavonoïdes/composition chimique , Antioxydants , AntibactériensRésumé
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.