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1.
Article Dans Anglais | IMSEAR | ID: sea-92283

Résumé

A prospective study of 101 consecutive patients of portal hypertension was carried out to study the possible relationships between bone marrow activity on 99m technetium labelled sulphocolloid scan and severity of liver disease, etiology of portal hypertension and cirrhosis, as well as presence and extent of collateral circulation, including esophageal varices. The patients were divided into 4 etiological groups: alcoholic cirrhosis (ALD), (38) non-alcoholic cirrhosis (NALD) (35) non-cirrhotic portal fibrosis (NCPF) (14) and extrahepatic portal vein obstruction (EHPVO) (14). Patients of cirrhosis were categorised according to modified Child-Pugh's classification. Esophageal varices were graded endoscopically as (1) no varix (2) small varices (< 5mm) (3) large varices (> 5mm). All patients underwent radionuclide imaging using 99m Technetium labelled sulphocolloid and bone marrow activity was studied. Evaluation of portasystemic collaterals was done ultrasonically. We found that 16.6%, 44.6% and 72.72% patients with Child A, B and C cirrhosis respectively, had increased marrow activity (p < 0.05). There was no significant difference between marrow activity of patients with ALD (52.6%) and NALD (40%). None of the non-cirrhotic patients demonstrated bone marrow uptake of radioisotope. There was no significant difference between bone marrow uptake presence of lienorenal collaterals and presence or size of esophageal varices. We thus conclude the bone marrow activity on radioisotope scanning depends only on the severity of liver disease and does not vary a according to the etiology of cirrhosis, or presence and extent of portasystemic collaterals, including esophageal varices.


Sujets)
Adulte , Études cas-témoins , Circulation collatérale , Varices oesophagiennes et gastriques/complications , Femelle , Humains , Hypertension portale/étiologie , Cirrhose du foie/complications , Cirrhose alcoolique/complications , Mâle , Études prospectives , Radiopharmaceutiques/diagnostic , Sulfocolloïde de technétium (99mTc)/diagnostic
3.
Indian Pediatr ; 1993 May; 30(5): 625-8
Article Dans Anglais | IMSEAR | ID: sea-14847

Résumé

Thirty cases of recurrent pulmonary infection and ten control cases underwent radionuclide gastroesophagography endoscopy, histopathology and barium esophagography to evaluate the clinical efficacy of scintigraphic technique in, detection of gastroesophageal reflux. After ingesting 500 micro curie of Tc-Sulphur colloid mixed in milk, patients esophageal activity was monitored using the gamma camera for forty-five minutes continuously. By using histopathology as standard of comparison, the sensitivity and specificity of radionuclide esophagography was 78.54 and 81.25%, respectively. Because of its physiologic nature, low radiation exposure and convenience, radionuclide esophagography is recommended as a suitable screening test for detecting gastroesophageal reflux where available.


Sujets)
Sulfate de baryum/diagnostic , Enfant , Enfant d'âge préscolaire , Oesophagite peptique/diagnostic , Oesophagoscopie , Études d'évaluation comme sujet , Femelle , Radioscopie , Reflux gastro-oesophagien/diagnostic , Gastroscopie , Humains , Nourrisson , Mâle , Sensibilité et spécificité , Sulfocolloïde de technétium (99mTc)/diagnostic
5.
Article Dans Anglais | IMSEAR | ID: sea-90471

Résumé

Various criteria are used together for the scintigraphic diagnosis of cirrhosis as no single criterion may be reliable. However, low right-to-left hepatic lobe uptake ratio has been reported to be sensitive and specific for alcoholic cirrhosis. A low liver-to-spleen uptake ratio has also been reported in various hepatocellular disorders. We tested these ratios in patients with cirrhosis and non cirrhotic causes of portal hypertension. The right-to-left lobe uptake ratio was significantly lower (1.59 +/- 1.23 vs 2.36 +/- 0.63 in normals; p = 0.037) in only Child's C alcoholic cirrhosis, but the sensitivity of this ratio was low (40%) even in this subgroup of cirrhosis (mean +/- SD 1.72 +/- 1.08) as against 1 of 10 patients with non cirrhotic portal hypertension (3.57 +/- 1.33; p = 0.0005). We conclude that the right-to-left hepatic lobe uptake ratio is not a discriminatory scintigraphic sign in liver disease. A low liver-to-spleen uptake ratio can distinguish cirrhosis from non cirrhotic causes of portal hypertension.


Sujets)
Diagnostic différentiel , Humains , Composés organiques du technétium/diagnostic , Acide phytique/diagnostic , Sensibilité et spécificité , Sulfocolloïde de technétium (99mTc)/diagnostic
8.
Southeast Asian J Trop Med Public Health ; 1985 Sep; 16(3): 387-94
Article Dans Anglais | IMSEAR | ID: sea-30565

Résumé

Investigations of lymphatic dysfunction in animals infected with filarial parasites has been hampered by a paucity of techniques to measure efficiency of lymphatic drainage. In this study a 99mTc-sulfur colloid technique was used to assess the efficiency of lymphatic drainage in Patas monkeys infected with filarial nematodes. In all 15 uninfected hind limbs there was rapid and consistent appearance of labeled colloid in the primary lymph node (popliteal) and subsequently in the secondary nodes (abdomino-pelvic) in 11 of 15 limbs. In contrast, in all eight limbs tested 1-9 months after infection there was reduced rate of migration of the colloid and initial appearance in the abdomino-pelvic region: subsequent accumulation was seen in the popliteal region in only four of the limbs. This data indicated that lymphatic vessels were blocked and that collateral vessels channeled the colloid to the secondary lymph nodes. The lymph flow patterns demonstrated by the isotope technique were supported at autopsy.


Sujets)
Animaux , Erythrocebus patas , Membres , Femelle , Filarioses/anatomopathologie , Système lymphatique/anatomopathologie , Mâle , Sulfocolloïde de technétium (99mTc)/diagnostic
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