comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy

The aim of the work was to compare two different regimens of intravaginal misoprostol in termination of second trimester pregnancy. In a prospective study, 60 pregnant women were admitted in the Zagazig University Hospital with the diagnosis of missed abortion of intrauterine fetal death, with gestation between 14 and 20 weeks were recruited into the study with 30 subjects in each group. Women in [group A] were given vaginal misoprostol 200 micro g every 6 h while women in [group B] were given vaginal misoprostol 400 micro g every 12h if women did not abort in 24h, the same regimen was repeated. The mean amounts of misoprostol administered in [group A] was 600 micro g [ +/- 356.22] and in [group B] was 626.67 micro g [ +/- 309.54] arid the difference was statistically insignificant. The mean induction-abortion interval in [group A] was 16.17h [ +/- 10.05] and in [group B] was 14.97h [ +/- 7.41] and the difference was statistically insignificant. After vaginal misoprostol administration, there was significantly increase in the incidence of incomplete abortion rate in [group A] than in [group B]. However there was significantly decrease in the incidences of other side effects [vomiting, diarrhoea, fever, pain] in [group A] than in [group B]. It is concluded that both regimens of vaginal misoprostol 200 micro g every 6h and 400 every 12h were effective in termination of second trimester abortion with less side effects in the first regimen

Effect of light on fertility: an experimental study

To assess the influence of various light-dark cycles on the reproductive system of sexually immature male albino rats, 64 immature rats were included in this study. The rats were grouped into 4 equal groups: Group I: exposed to long photoperiod, Group II: exposed to short photoperiod. a Group III: exposed to complete darkness Group IV: control group exposed to natural day light. These groups were divided into 2 equal subgroups and received treatment for 1 and 3 months respectively. The rats were sacrificed following daily exposure, blood was collected, and plasma was separated and used for determination of L.H.-and testosterone by RIA. The testes were dissected, weighed and prepared for histological study. The rats exposed to long photoperiod had reached puberty earlier than the control. While those exposed to short photoperiod and complete darkness remained immature. Testicular weight and number of round spermatids had significantly increased in long photoperiod group compared with control, while those exposed to short photopericd and complete darkness group had significantly reduced testicular weight and less number of round spermatids compared with controls. LH and testosterone were significantly increased in Icng photoperiod group compared with control, short photcperiod and complete darkness group. The alterations observed in short photoperiod and complete darkness exposed rats were presumably due to inhibitory effect of melatonin on the neuroendocrine gonadal axis in those animals