Antilithiatic activity of leaves of Dalbergia rubiginosa Roxb

Renal calculus is a common and recurrent problem occurring in about 4% of the world population. The traditional system of Indian medicine suggests several herbs against lithiasis. One such plant is Dalbergia rubiginosa Roxb. which belongs to the family Leguminosae. The effect of alcoholic and aqueous extracts of the leaves of Dalbergia rubiginosa Roxb. [DRL] against lithiasis induced by 1% glycolated water for 35 days in male Wistar rats was tested in this study. Rats were fed with ethylene glycol [1%] mixed with drinking water for 35 days. Simultaneous treatment with the extracts of DRL considerably reduced the urinary risk parameters such as calcium, oxalate, phosphate, proteins and raised magnesium. These observations lead to the conclusion that the extracts are effective against Iithiasis. Phytochemical analysis of alcoholic and aqueous extracts of the leaves was also carried out

Investigation on hepatoprotective activity of pandanus fascicularis root

The extracts of Pandanus fascicularis Lam. [Pf] root were screened for hepatoprotective action. Albino rats were administered with carbon tetrachloride [CC14] for inducing liver damage. The effect of the extracts was evaluated by measuring the liver enzyme like SOOT, SOPT and bilirubin in the blood serum. The enzyme levels were compared with normal, toxicant and standard groups. In the extract treated animals, there is significant decrease in liver enzyme level. This observation leads to the conclusion that the Pf root possesses hepatoprotective activity. The hepatoprotective activity of the aqueous extract and ethanolic extract was compared with standard drug Silymarin. Aqueous extract shows promising activity when compared to ethanolic extract

Local anti-inflammatory and anti-nociceptive activities of coldenia procumbens linn.

The ethanolic extract of the leaves of Coldenia procumbens Linn, was studied in Swiss albino mice against 12-O-tetradecanoylphorbol-13-acetate [TPA] and arachidonic acid [AA] induced inflammatory response, while the analgesic effect was studied using the acetic acid-induced writhing in mice and formalin-induced nociception. The ethanolic extract produced dose dependent anti-inflammatory activity against the pathogens. It also showed an inhibitory effect on pain caused by acetic acid in mice and reduced pain episodes induced by formalin. The results indicated that the ethanolic extract produced significant [P<0.05] anti-inflammatory and anti-nociceptive activity when compared with the standard and untreated control

Antihyperglycemic and hypoglycemic effect of bougainvillea spectabilis linn, in normal and glucose induced diabetic rats

The hypoglycemic effect of ethanolic extract of Bougainvillea spectabilis was investigated on glucose loaded and streptozotocin induced diabetic rats. The blood glucose levels were measured at 0, 1,2 and 3 hrs after the treatment. The ethanolic extract of B. spectabilis [300 mg/kg] reduced the blood glucose of normal rat from 85.33 +/- 1.79 to 65.17 +/- 3.67 mg/dl, 3 hrs after oral administration of the extract [P<0.001]. It also significantly lowered blood glucose level in streptozotocin induced diabetic rat from 330.67 +/- 3.27 to 132.17 +/- 4.49 mg/dl, 3 hrs after oral administration of the extract [p<0.001]. The antihyperglycemic activity of B. spectabilis was compared with tolbutamide, an oral hypoglycemic agent

Anti-inflammatory activity of coldenia procumbens linn

Anti-inflammatory activity of the ethanolic extract of the aerial parts of Coldenia procumbens Linn. was studied in wister rats using the carrageenan induced left hind paw edema, carrageenan induced pleurisy and cotton pellet induced granuloma model. The ethanolic extract [150 mg/kg, p.o.,] produced the inhibition of carrageenan induced rat paw edema. It also showed an inhibitory effect on leukocyte migration and a reduction on the pleural exudates as well as reduction on the granuloma weight in the cotton pellet granuloma method. The results indicated that the ethanolic extract produced significant [P<0.001] anti-inflammatory activity when compared with the standard and untreated control

Modulating effect of Cyperus rotundus Linn. on ethanol induced liver damage

The effect of alcoholic extract of Cyperus rotundus Linn. on ethanol induced deranged lipid metabolism was summarized. Administration of 18% ethanol for 28 days induces elevation of cholesterol and triglycerides levels. Also ethanol being toxic to liver enzymes like AST and ALT were altered: Simultaneous administration of alcoholic extract of Cyperus rotundus reduced the elevated triglyceride level though the hepatic enzyme levels and cholesterol level were trot reduced. This observation leads to the conclusion that it possesses triglyceride-lowering effect

Modulating effect of root extract of asparagus racemosus against ethanol induced liver damage in rats

The effect of ethanolic extract of the root of Asparagus racemosus Willd. [REAR] against ethanol induced lipid peroxidation has been summarised. Administration of ethanol [18%] for 45 days induces lipid peroxidation leading to liver damage. Hence the enzyme levels such AST, ALT and alkaline phosphatase which are good markers of liver condition have been elevated and also the triglycerides and cholesterol. Simultaneous administration of REAR at the dose of 165 mg/kg reduced these elevated parameters substantiating that REAR is inhibiting the ethanol induced liver damage in rats