Study of serum interleukin -1-beta [IL-IB] in typhoid fever

IL-1B was measured in 20 cases with simple typhoid fever, 20 cases with complicated typhoid fever [bleeding, perforation encephalitis and haemolysis] and 20 normal healthy individuals. This study was done to investigate level of IL-IB in patients with typhoid fever and it's role in differentiating between simple and complicated typhoid fevers. This study showed a highly significant increase in serum IL-1B levels in simple and complicated typhoid groups compared to normal healthy individuals. Moreover, serum IL-1B concentration was highly significantly increased in complicated group when compared to simple typhoid group. A significant positive correlation was found between serum IL-1 B [pg/ml] and each of magnitude of fever, reversed Widal titre and SGFT [1.u /L], while a significant negative correlation was detected between it and total serum proteins [G/dl] and serum albumin [G/dl]. This study concluded that serum IL -lB concentration showed a highly significant changes during the febrile period of typhoid fever and is a useful detectable parameter in differentiating between simple and complicated typhoid groups, since it's shooting in the last group

Study of thyroid hormones concentrations in egyptian patients with chronic active hepatitis postvirus C Infection

Serum total T3 [TT3], serum free T3 [FT3], serum total T4 [TT4], serum free T4 [FT4] and serum thyroid stimulating hormone [TSH] were assessed by radio-immunoassay in [30] Egyptian patients with chronic active hepatitis [CAH] post -virus C [group I] and [30] normal healthy subjects [group II]. Our results showed highly significant decrease [P<0.01] of TT3 and FT3 concentrations in the diseased group as compared to normal control group Also, our findings showed highly significant increase [P<0.01] of TT4, FT4 and TSH concentrations in cases with CAH post-virus C when compared to normal control group. In present work, upon doing matrix correlation, the results showed significant moderate negative correlations were observed between FT3 concentration [pg /ml], and SGOT [lu /L] and SGPT [lu /L] while non significant weak correlations were found between FT3 concentration [pg /ml] and total bilirubin [mg /dl] and prothrombin activity. Also, the findings showed significant moderate positive correlations were detected between FT4 concentration [pg / ml] and SGOT [lu /L] and SGPT [lu /L] while non significant weak correlations were observed between FT4 concentration [pg / ml] and total bilirubin [mg / dl] and prothrombin activity [seconds]. Lastly, there was noted significant moderate negative correlation between total serum protein [gm /dl] and FT3 [pg/ml] concentrations In conclusion, thyroid function affection may associated with CAH post virus C and this affection is directly proportional to the degree of hepatic damage