Anticonvulsant and hypnotic agents: novel thiobarbituric acid derivatives of 4 [3H] -quinazolines

5 novel series of 4[3H]-quinazolinone derivatives have been prepared: 2-methyl/phenyl-3-[3-substituted-4,6-dioxo-2-thioxohexahydropyrimidin- 1-yl]-4[3H]-quinazolinones [IIIa]; 2-phenyl-3-[3-aryl-5-benzylidene- 4,6-dioxo-2-thioxohexahydropyrimidin-1-yl]-4[3H]-quinazolinones [IVa- c]; 3-aryl-2-[3-aryl,-4,6-dioxo-2-thioxohexahydropyrimidin-1-yl] -iminomethyl-4[3H]-quinazolinones [VIa-f]; 3-aryl-2-[3-aryl-5- benzylidene-4,6-dioxo-2-thioxohexahydropyrimidin-1-yl] iminomethyl-4- [3H]-quinazolinones [VIIa-f] and 3-aryl-2-[3-[3-aryl-4,6-dioxo-2-thioxohexahydropyrimidin-1-yl]-4-oxo- 1,3-thiazolidin-2-yl]-4[3-H]-quinazolinones [VIIIa-f]. Some products showed anticonvulsant and hypnotic activities when tested in mice

Novel thiazolidine-4 [3H] -quinazolines as potential antimicrobial agents

Four novel series of 4[3H]-quinazolinone derivatives have been prepared. The synthesized compounds are: 3 aryl-2-[3-[1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4-yl-4-oxo-1, 3 thiazolidin-2-yl]-4[3H]-quinazolinones [IIIa-c], 3-aryl-2-[3-4-pyridylacrbonylamino]-4-oxo-1, 3-thiazolidin-2-yl]- 4[3H]-quinazolinones [Va-c], 3-aryl-2-[3-[arylthiocarbamoylamino]-4-oxo-1, 3- thiazolidin-2-yl]-4[3H]-quinazolinones [VIIa-f], 2-methyl/phenyl-3-[2-[1, 5-dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H- pyrazol-4-yl]-4-oxo-1, 3- thiazolidin-3-yl]-4[3H]-quinazolinones [XIa- b] and 2-methyl/phenyl-3- [2-[3-aryl-1-phenyl-1H- pyrazol-4-yl]-4-oxo-1, 3-thiazolidin-3-yl]-4[3H]- quinazolinones [XIa- f]. The antimicrobial activity of prepared compounds was evaluated