Echinococcosis in camels as revealed by indirect haemaglutination test in Belbas

This study aimed to estimate the prevalence of Echinococcus antibodies in camels using the indirect haemagglutination test [I.H.A.T.], out of 100 camels, 27 camels were seropositive

Cell-mediated immune response in experimental infection with H heterophyes

Experimental infection of puppies with Heterophyes heterophyes was associated with marked cell-mediated immune response that manifested itself by increase of T-cell count and leucocyte migration. The degree of cell-mediated immune response was inversely proportional to the intensity of infection. The significance of the results was discussed

Effect of some drugs on some histopathological and immunological aspects of experimental trichinosis in albino rats

The present work is concerned with study of the effects of praziquantel, thiabendazole, mebendazole, cyclophosphamide and cortisone on histopathology of the small intestine [during intestinal phase] and skeletal muscles [during muscular phase], in addition to T. lymphocytes count and serum IgG estimation in experimental trichinosis in albino rats. Praziquantel has no effect on the histopathology of small intestine or skeletal muscles. Thiabendazole and mebendazole treatment resulted in complete eradication of Trichinella spiralis worms of small intestine and marked reduction of larval infection [mild infection] of skeletal muscle. Praziquantel, thiabendazole and mebendazole did not affect significantly the T. lymphocytes count of the host during the intestinal phase. Cyclophosphamide and cortisone suppressed the cellular immunity [T. lymphocytes] and accordingly enhanced the parasitic infection in histopathology of both phases. All the drugs tested induced significant reduction of T. lymphocytes in muscular phase [which may be due to parasitic infection itself] and insignificant effect on IgG level in both phases

Serological studies on toxoplasmosis in Zagazig slaughterhouse

This study intended to estimate the prevalence of Toxoplasma antibodies among farm animals in Zagazig slaughterhouses using indirect haemagglutination test [I.H.A.T.] and to evaluate the occupational exposure to infected animals and meat among abattoir workers. 25% of the tested animals were seropositive 19.2% of the exposed persons showed positive reactions while in a control group it was 12% with statistically insignificant difference

Biological and hematological changes in experimental cryptosporidiosis

In experimentally infected laboratory-bred white rats, Cryptosporidium infection rate was higher among immunosuppressed [75%] than immunocompetent ones [37.5%] with statistically insignificant difference. Cryptosporidiosis was found to be a fatal disease especially in immunosuppressed rats [50%]. There was also marked flourishing of the infection as revealed by high intensity of infection in immunosuppressed than the immunocompetent rats [363 and 82.7 oocysts / pellet respectively]. In spite of the severe disease, cyclophosphamide appeared to have no effect on the prepatent period. In both immunosuppressed and immunocompetent infected rats, there was a decrease in the total leucocytic count with marked lymphocytopaenia. This indicates decreased resistance to infection, thus higher oocyst counts in the pellets

Toxoplasmosis among cases of chronic tonsillitis

One hundred cases aged 4-20 years and suffering from chronic tonsillitis were examined for Toxoplasma antibodies using indirect immunofluorescent test [IFAT]. It was found that 37% of them were positive for toxoplasmosis. 41.5% of hypertrophic cases and 32% of atrophic ones had toxoplasmosis but the difference was statistically insignificant. The mean antibody titres were higher in both atrophic and hypertrophic cases than in the control group. The patients aged from 11-20 years had a higher titre of Toxoplasma antibodies than those aged below ten years. Trials to detect tachyzoites, cysts or pseudocysts in fixed paraffin sections using Hx and E, PAS or Giemsa stains were not successful. The histopathological picture of tonsils removed from positive cases of toxoplasmosis showed characteristics of toxoplasmic lymphadenitis

Effect of some anthelmintics on hymenolepis nana in Albino mice

Mebendazole and Emetine [orally and parentrally] were used to treat mice infected with H. nana. Yomesan, in a single oral dose, was also used as a standardized well-known cysticidal drug. Emetine had a marked effect on cysticercoids leading to highly significant reduction in their number. Also, it caused complete removal of adult worms in infected mice. Mebendazole had no effect on the cysticercoid stage, but it caused significant reduction in the number of adult worms. Yomesan, showed a marked lethal effect on both the cysticercoids and adult worms leading to highly significant reduction in their number

Certain immunological changes following oxamniquine treatment of mansoniasis in white mice

The objective of the present work was to reveal certain aspects of the immunological reactions before and after oxamniquine therapy of mansoniasis in experimental animals. The sequences of events were studied in infected non-treated, infected treated and non-infected non-treated groups of mice. This was achieved by study of the immuno-electrophoretic pattern and by direct immunofluorescent examination of the thymus gland. From the present investigation it seems that oxamniquine treatment of mansoniasis stimulates marked production of immunoglobulins and increased activity of the thymus gland which seems to contribute to the immunologic response