RESUMO
Abstract Up to today, there is no specific treatment against SARS-CoV-2 / COVID-19 infection; there the necessity to search for alternatives that help patients with COVID-19. The objective of this study was to review the use of ozone therapy as adjunct treatment for SARS-CoV-2 / COVID-19 infection, highlighting the mechanisms of action, forms of application and current clinical evidence. A systematic review was conducted in electronic databases, searching the terminology Ozone "or" Ozone therapy "and" SARS-CoV-2 or COVID-19 or Coronavirus. Results: nineteen studies were included; ten were editorials, comments, brief reports or reviews, and nine clinical studies. We found that ozone therapy could be favorable for treating patients infected with SARS-CoV-2 / COVID-19, through a direct antiviral effect, regulation of oxidative stress, immunomodulation and improvement of oxygen metabolism. Patients who were treated with ozone therapy responded favorably; therefore, ozone therapy appears to be a promising treatment for patients infected with SARS-CoV-2 / COVID-19. Its mechanism of action justifies its use as an adjuvant therapy; however, scientific evidence is based on case series and clinical trials are necessary to corroborate its effectiveness and safety.
Assuntos
Coronavirus/patogenicidade , SARS-CoV-2/classificação , COVID-19/patologia , Ozonioterapia , Antivirais/análise , Pacientes/classificação , Estresse Oxidativo , Relatório de Pesquisa , Infecções/classificaçãoRESUMO
El deporte actual se caracteriza por una alta carga competitiva y, en consecuencia, la recuperación tras una lesión debe ser rápida y eficiente, por lo que los modelos convencionales de rehabilitación en el deporte(RD) probablemente resulten insuficientes.El objetivo de esta carta editorial es reflexionar sobre el papel del especialista en Medicina Física y Rehabilitación (EMFR) en el proceso de RD
Today's sport is characterized by a high competitive load and, consequently, recovery from injury must be fast and efficient, so that conventional models of rehabilitation in sport (RD) are likely to be insufficient. The aim of this editorial letter is to reflect on the role of the specialist in Physical Medicine and Rehabilitation (EMFR) in the DR process.
Assuntos
HumanosRESUMO
Abstract Background: To evaluate the efficacy and safety of prolotherapy with hypertonic dextrose in patients with knee osteoarthritis. A systematic search was performed in electronic databases including PUBMED, SCIELO, DIALNET and Google Scholar. Main body: We searched for randomized clinical trials that evaluated therapeutic interventions in patients with knee osteoarthritis. These trials compared the effect of intra-articular and / or extra-articular infiltrations of hypertonic dextrose vs the effect of intra-articular and / or extra-articular infiltrations of other substances or some interventional procedure application, via assessing pain, physical function and secondary effects and / or adverse reactions. Ten randomized clinical trials were included in this systematic review, the total sample size comprised 328 patients treated with hypertonic dextrose (prolotherapy) vs 348 controls treated with other infiltrations such as local anesthetics, hyaluronic acid, ozone, platelet-rich plasma or interventional procedures like radiofrequency. Conclusions: In terms of pain reduction and function improvement, prolotherapy with hypertonic dextrose was more effective than infiltrations with local anesthetics, as effective as infiltrations with hyaluronic acid, ozone or radiofrequency and less effective than PRP and erythropoietin, with beneficial effect in the short, medium and long term. In addition, no side effects or serious adverse reactions were reported in patients treated with hypertonic dextrose. Although HDP seems to be a promising interventional treatment for knee OA, more studies with better methodological quality and low risk of bias are needed to confirm the efficacy and safety of this intervention.
Assuntos
Humanos , Osteoartrite do Joelho/tratamento farmacológico , Proloterapia/instrumentação , Solução Hipertônica de Glucose/uso terapêutico , Avaliação em Saúde , Resultado do TratamentoRESUMO
El objetivo de esta revisión fue establecer una asociación entre el nivel de actividad física realizada y la reducción del riesgo de muerte en pacientes hipertensos. Para la identificación de los documentos de esta revisión se realizó una búsqueda que abarcó estudios epidemiológicos tipo cohorte; las publicaciones relevantes fueron identificadas en las bases de datos biomédicas PubMed y Cochrane Collaboration, la estrategia de búsqueda siguió las recomendaciones de PRISMA. Los resultados mostraron que existe una asociación entre el nivel de actividad física y el riesgo de muerte en pacientes hipertensos. Se encontró una disminución del riesgo de muerte que oscila entre el 17-67% en los hipertensos que realizan altos niveles de actividad física. Los resultados apoyan la teoría de que la actividad física regular se asocia con la reducción del riesgo de muerte en pacientes hipertensos y se sugiere que este efecto protector puede ser para muerte por enfermedad cardiovascular y para muerte por cualquier causa, además se observó que en los estudios que consideraron edades de 40 a 80 años, la reducción del riesgo relativo fue del 28-67%. Por lo que se sugiere que probablemente la actividad física genere mayores beneficios en los grupos etarios de mayor edad.
The objective or aim of this review was to determine a relation between the level of realized physical activity and the reduction of the risk of death in hypertensive patients. A search was conducted for the identification of the documents from this review that included epidemiological cohort studies, relevant publications were identified in the biomedical databases PubMed and Cochrane Collaboration, the search strategy follows the recommendations of PRISMA. The results showed that an association exists between the level of physical activity and the risk of death in patients with hypertension. There was a diminution of death that ranges between 17-67 % in the hypertensive ones that do high physical activity levels. The results support the theory that regular physical activity is associated with a reduction in the rates of mortality in hypertensive patients and it is suggested that this protective effect can be of great benefit in a lower incidence of disease and cardiovascular death. In addition it is noted that the studies that consider ages of 40 to 80 years, the reduction of relative risk was 28-67%. Thus it is suggested that physical activity is likely to generate higher profits in the older age groups.