RESUMO
Fusarium species are common plant pathogens present in the environment but can cause invasive infections in immunocompromised patients, especially those with haematologic malignancies and bone marrow transplant recipients1. Tissue and blood cultures are especially important as they offer a high diagnostic yield in invasive fusariosis2-3. Amphotericin B has been used as the mainstay of treatment4 although resistant rates are high, especially in Fusarium solani species5. The treatment outcome is also closely related to rate of recovery of neutropenia
RESUMO
There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.