1.
Indian J Exp Biol
;
1995 Jan; 33(1): 38-40
Artigo
em Inglês
| IMSEAR
| ID: sea-61471
RESUMO
Compound 88-765 (4-amino-6-methylthio-1-(2', 2'-diethoxyethyl)-1 H-pyrazolo[3, 4-d]pyrimidine) has shown potent antiallergic activity in experimental models. The compound inhibited the passive cutaneous anaphylaxis (PCA) reaction in rats in dose-dependent manner (5-100 mg/kg, po) by 47 to 87%. In mice it inhibited PCA by 78% at 50 mg/kg, po. It also inhibited mast cell degranulation of normal and passively sensitised rats induced by compound 48/80 and egg albumin, respectively. These effects of Compound 88-765 were comparable with that of disodium cromoglycate (DSCG). The results suggest that compound 88-765 possesses potent antiallergic activity.
Assuntos
Animais , Antialérgicos/farmacologia , Cromolina Sódica/farmacologia , Masculino , Mastócitos/efeitos dos fármacos , Camundongos , Anafilaxia Cutânea Passiva/efeitos dos fármacos , Pirazóis/farmacologia , Pirimidinas/farmacologia , Ratos
2.
Artigo
em Inglês
| IMSEAR
| ID: sea-20644