Synthesis of some new 1, 2, 3-selena and thiadiazole derivatives

Several compounds of 1,2,3-selena and/or thioadizoles with evident biological activity were previously reported by the authors, certainly as antibacterial and antifungal agents [1-6] e.g. 1,2,3-thiadiozolo and/or selenadiazolo-4-yl-pheynyl-hydrazophyrazolones [10] were tested in vitro against a variety of Gram positive strains of bacteria. Certain compounds show strong activity against Bacillus sub., staphylococcus areus and Mycobacterium phlei. Thus, pyridine [7], furan [8] and thiophene [9] containing 1,2,3-selena and thiadiazoles motivated their synthesis and testing as biologically active compounds. In this work, compounds [1-3] were easily condensed with semicarbazide to give the corresponding semicarbazones [4-6] respectively. On the other hand, the purified semicarbazones [4-6] were then oxidized either with selenium dioxide [11] in glacial acetic acid to give 1,2,-3-selenadiazole Derivatives[9,11] or with thionyl chloride[12] to afford, 1,2,3-thiadiazole derivatives[10,12]

Bridge heat nitrogen compounds: synthesis and biological activity of some novel oxadiazolo triazolothiadiazino and triazolothiadiazolo thienopyrimidine derivatives

Some novel s-triazolo [3, 4-b] 1,3,4,-thidiazines 2a-d were synthesized via the reaction between compounds 1e-h and hydrazine hydrate. Also, s-triazolo [3, 4-b] 1, 3,4-thiadiazoles 4b, c were prepared by reaction of 3 with aryl acid chlorides. The new compounds were characterized by elemental analysis, ir and 1Hnmr spectral data

Synthesis and antibacterial activity of some new selenadiazoles and thiadiazole containing amino acid moieties

Both selena-and thiadiazoles are known by their antiviral, antibacterial and antifungal activities. Besides, amino acids or their derivatives display an important role in biological aspects. It seemed interesting to synthesise 1,2,3-selena-and/or thiadiazoles containing amino-acid moieties with the hope that some of them will show improved antimicrobial properties

Synthesis and antibacterial activity of some new selenadiazole and thiadiazole containing amino acid moieties

The synthesis of 4-[substitute glycylaminophenyl-4-yl] 1,2,3- selenadiazoles [VI] and 4-[subtitute glycylaminophenyl-4-yl] 1,2,3- thiadiazoles [V] have been accomplished starting from 4-cloroacetylaminoacetophenone [I]. Compound/on reaction with different amines gives 4-glycylamiocetophenone derivatives [II], which on condensation with semicarbazide furnish the corresponding semicarbazones [III]. Oxidative cyclizatin of III either by selenium dioxide or thionyl chloride yields IV and V, respectively. Some of the compounds screened in vitro for their antibacterial and antifungal properties

Studies on B-lactams and thiazolidinones Part 1 Synthesis and biological activity of some new triazolyl-azetidin-2-onesand-thiazolidin-4-ones

Arylidene-3-amino-1,2,4-tiazoles [1] were prepared by condensation of 3-amino-1,2,4-triazole with aromatic aldehydes. Cyclocondensation of chloroacetylchloride, phthalinudoacetylchloride, and mercaptoacetic acid on [1] giving the corresponding azetidin-ones [2 and 3] and 4-thiaolidinones [4], respectively, in good yield