RESUMO
To test in vitro combination of fusidic acid and amikacin against infections caused by methicillin resistant Staphlococus aureus [MRSA]. In vitro study conducted in Department of Pharmacology and Microbiology, Dr. Ziauddin Medical University. The duration of study was March 2004- February 2005. Antibiotic susceptibility testing was done by Kirby Bauer"s disc diffusion method and by minimum inhibitory concentration [MIC] by broth macrodilution and checkerboard technique for synergy. FIC [fractional inhibitory concentrations] were calculated. MIC of fusidic acid was 0.03-1micro g/ml and amikacin 0.5-16 micro g/ml respectively. The combination of these demonstrated synergy. Evidence of synergy correlated directly with the MICs of fusidic acid and amikacin. Combination therapy with fusidic acid and amikacin may be a reasonable alternative in the treatment of infections caused by MRSA isolates and encourages clinical evaluation