Blood Transfusion Selection in Patients with Autoimmune Hemolytic Anemia Producing Class Antibodies / 中国实验血液学杂志

<p><b>OBJECTIVE</b>To analyze the reasons for the incompatibility of cross matching in lymphoma patients complicated by autoimmune hemolytic anemia (AIHA), and to provide compatible blood to patients for multiple blood transfusion.</p><p><b>METHODS</b>The test tube method was used for routine identification of ABO blood group, Rh typing and direct anti-globulin test; the patients antibody was identified by saline water method, micro column gel card; and the saline water method, Polybrene method and antiglobulin method were used for blood cross matching test of the patients.</p><p><b>RESULTS</b>In the serum of the patient, positive autoantibodies were detected, in the elution, the Ce antibody was detected. After infusion of the corresponding antigen-negative blood, the patient's hemoglobin level was significantly improved.</p><p><b>CONCLUSION</b>Only firstly accurately identifying antibodies existed in serum and elution, then selecting corresponding antigen negative blood, can ensure the safety and effectiveness of blood transfusion.</p>

Advances in anti-influenza virus of neuraminidase inhibitors / 中国药学杂志

Neuraminidase (NA) is a mushroom-shaped and tetramer structural envelope glycoprotein on the surface of the influenza virus. NA inhibitors can inhibit highly pathogenic influenza virus subtypes and have good safety and drug resistance, hence they are widely used for the prevention and treatment of influenza virus. Based on the present domestic and foreign literatures in this field, this paper summarizes the research status of neuraminidase inhibitors classification and structure-activity relationships. It will help us make better use of existing conditions to design and synthesize better active and more selective anti-influenza drugs.

Effect of five species of Epimedium on growth of cartilage and proliferation of cartilage cell in vitro / 中国中药杂志

<p><b>OBJECTIVE</b>To observe the effect of Epimedium brevicornum, E. sagittatum, E. koreanum, E, wushanense and E. elongntum on the growth of cartilage and proliferation of cartilage cell in vitro.</p><p><b>METHOD</b>According to the paired design method, either femur of each chichen embryo was put into the control tube with the medium containing no Epimedium injection, and the other was put into the treated tube with the medium containing 3% Epimedium injection. The length and weight of cultured cartilage and proliferation of cartilage cell (MTY method) were used as the indices to observe the cartilage biological activities of the five species of Epimedium in culture.</p><p><b>RESULT</b>The results showed that the indices of length, weight and MTT in the E. brevicornum and E. sagittatum group were significantly higher than those in the contral group, but the above indices in groups E. koreanum, E. wushanens and E. elongntum were similar to those of the control with no statistical difference.</p><p><b>CONCLUSION</b>E. brevicornum and E. sagittatum can improve the growth of cartilage and proliferation of cartilage cell in vitro, and other three Epimedium have not the same effect in this test.</p>